Translated title of the contribution: Results of the treatment of T2, N0-1 breast cancer

F. Volterrani, N. Di Muzio, A. Bolognesi, G. Ceresoli, M. Reni, A. Marassi, P. Veronesi

Research output: Contribution to journalArticlepeer-review


We report on 240 T2, N0-1 breast carcinomas treated from January 1979 to December 1988. 126 patients had nodal axillary metastases (52,5%), 45 of them had more than 3 nodes involved (35.7%). T pathological diameter was assessed in 173 cases (72.1%): in 163 was ≤ 4 cm (94.2%). In the group of pT assessed cases, axillary nodal positivities were in total 97 (56.1%): 71/132 with 2.1-3 cm pT (53.8%), 18/31 with 3.1-4 cm pT (58.1%), and 8/10 with 4.1-5 cm pT (80.0%). A total of 50 patients were submitted to conservative surgery plus radiotherapy (20.8%), while 190 were submitted to radical surgery, preferably to modified radical mastectomy. For all considered patients, crude 3 and 8 years actuarial survival was respectively 91.0% and 75.9%, and NED survival was respectively 73.0% and 56.6%. For the conservative treatment group, the NED survival was respectively 79.9% and 71.9%, and no patients developed breast relapses. Loco-regional failures were observed in a total of 41/210 cases with a minimum follow-up ≥ 3 years (19.5%): 32/111 N + (28.8%), 17/38 N + with more than 3 nodes (44.7%). Distant metastases were observed in a total of 53/210 patients (25.2%): 25/99 N - (25.2%), 15/73 N + with 1-3 nodes (20.5%), 13/38 N+ with more than 3 nodes (34.2%). We can now extend the conservative treatment to the 2.1-3 cm pT2 cases, and also to the 3.1-4 cm pT2 when local conditions are suitable for good final aesthetic results. Besides, postoperative radiotherapy must be reconsidered in the trearment of the N + patients with more than 3 nodes.

Translated title of the contributionResults of the treatment of T2, N0-1 breast cancer
Original languageItalian
Pages (from-to)494-500
Number of pages7
Issue number9
Publication statusPublished - 1992

ASJC Scopus subject areas

  • Surgery


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