Resveratrol and ischemic preconditioning in the brain

Ami P. Raval, Hung Wen Lin, Kunjan R. Dave, R. Anthony DeFazio, David Della Morte, Eun Joo Kim, Miguel A. Perez-Pinzon

Research output: Contribution to journalArticle

88 Citations (Scopus)

Abstract

Cardiovascular pathologies in the French are not prevalent despite high dietary saturated fat consumption. This is commonly referred to as the "French Paradox" attributing its anti-lipidemic effects to moderate consumption of red wine. Resveratrol, a phytoalexin found in red wine, is currently the focus of intense research both in the cardiovascular system and the brain. Current research suggests resveratrol may enhance prognosis of neurological disorders such as, Parkinson's, Huntington's, Alzheimer's diseases and stroke. The beneficial effects of resveratrol include: antioxidation, free radical scavenger, and modulation of neuronal energy homeostasis and glutamatergic receptors/ion channels. Resveratrol directly increases sirtuin 1 (SIRT1) activity, a NAD+ (oxidized form of nicotinamide adenine dinucleotide)-dependent histone deacetylase related to increased lifespan in various species similar to calorie restriction. We recently demonstrated that brief resveratrol pretreatment conferred neuroprotection against cerebral ischemia via SIRT1 activation. This neuroprotective effect produced by resveratrol was similar to ischemic preconditioning-induced neuroprotection, which protects against lethal ischemic insults in the brain and other organ systems. Inhibition of SIRT1 abolished ischemic preconditioning-induced neuroprotection in CA1 region of the hippocampus. Since resveratrol and ischemic preconditioning-induced neuroprotection require activation of SIRT1, this common signaling pathway may provide targeted therapeutic treatment modalities as it relates to stroke and other brain pathologies. In this review, we will examine common signaling pathways, cellular targets of resveratrol, and ischemic preconditioning-induced neuroprotection as it relates to the brain.

Original languageEnglish
Pages (from-to)1545-1551
Number of pages7
JournalCurrent Medicinal Chemistry
Volume15
Issue number15
DOIs
Publication statusPublished - Jun 2008

Fingerprint

Ischemic Preconditioning
Brain
Sirtuin 1
Wine
Pathology
NAD
Chemical activation
Stroke
Cardiovascular system
Free Radical Scavengers
Histone Deacetylases
resveratrol
Dietary Fats
Huntington Disease
Neuroprotective Agents
Cardiovascular System
Nervous System Diseases
Brain Ischemia
Ion Channels
Research

Keywords

  • Cerebral ischemia
  • Ischemic preconditioning
  • Neuroprotection
  • SIRT1
  • Sirtuin 1
  • Stroke

ASJC Scopus subject areas

  • Organic Chemistry
  • Biochemistry, Genetics and Molecular Biology(all)
  • Biochemistry
  • Pharmacology

Cite this

Raval, A. P., Lin, H. W., Dave, K. R., DeFazio, R. A., Della Morte, D., Kim, E. J., & Perez-Pinzon, M. A. (2008). Resveratrol and ischemic preconditioning in the brain. Current Medicinal Chemistry, 15(15), 1545-1551. https://doi.org/10.2174/092986708784638861

Resveratrol and ischemic preconditioning in the brain. / Raval, Ami P.; Lin, Hung Wen; Dave, Kunjan R.; DeFazio, R. Anthony; Della Morte, David; Kim, Eun Joo; Perez-Pinzon, Miguel A.

In: Current Medicinal Chemistry, Vol. 15, No. 15, 06.2008, p. 1545-1551.

Research output: Contribution to journalArticle

Raval, AP, Lin, HW, Dave, KR, DeFazio, RA, Della Morte, D, Kim, EJ & Perez-Pinzon, MA 2008, 'Resveratrol and ischemic preconditioning in the brain', Current Medicinal Chemistry, vol. 15, no. 15, pp. 1545-1551. https://doi.org/10.2174/092986708784638861
Raval, Ami P. ; Lin, Hung Wen ; Dave, Kunjan R. ; DeFazio, R. Anthony ; Della Morte, David ; Kim, Eun Joo ; Perez-Pinzon, Miguel A. / Resveratrol and ischemic preconditioning in the brain. In: Current Medicinal Chemistry. 2008 ; Vol. 15, No. 15. pp. 1545-1551.
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