Resveratrol, Rapamycin and Metformin as Modulators of Antiviral Pathways

Francesca Benedetti, Vincenzo Sorrenti, Alessandro Buriani, Stefano Fortinguerra, Giovanni Scapagnini, Davide Zella

Research output: Contribution to journalReview articlepeer-review


Balanced nutrition and appropriate dietary interventions are fundamental in the prevention and management of viral infections. Additionally, accurate modulation of the inflammatory response is necessary to achieve an adequate antiviral immune response. Many studies, both in vitro with mammalian cells and in vivo with small animal models, have highlighted the antiviral properties of resveratrol, rapamycin and metformin. The current review outlines the mechanisms of action of these three important compounds on the cellular pathways involved with viral replication and the mechanisms of virus-related diseases, as well as the current status of their clinical use.

Original languageEnglish
Issue number12
Publication statusPublished - Dec 17 2020


  • antiviral
  • dietary supplement
  • metformin
  • rapamycin
  • resveratrol

ASJC Scopus subject areas

  • Infectious Diseases
  • Virology


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