Rethinking vascular wall: Periadventitial adipose tissue (tunica adiposa)

George N. Chaldakov, Marco Fiore, Gorana Rančić, Peter I. Gehenev, Neşe Tunçel, Jerzy Beltowski, Mariyana G. Hristova, Pepa Atanassova, Luigi Aloe

Research output: Contribution to journalArticle

Abstract

The prevailing response-to-injury hypothesis of Russell Ross states that atherosclerosis is an inflammatory intimai disease. Accordingly, intima-media thickness became an accepted measure of structural arterial remodeling and a strong predictor of atherosclerosis. However, it is unlikely that such one-direction road may solely travel the whole multiplex network like that of atherogenesis. A decade ago, we have proposed an interactive hypothesis ofatherogenesis, involving all structural components of the arterial wall including periadventitial adipose tissue (PAAT). As already alluded to, the arterial wall consists of three concentric tissue coats (tunicae): intima, media, and adventitia. In the present short review, we highlight accumulated data about PAAT, and conceptualize PAAT as the fourth coat of arterial wall, that is, tunica adiposa; in brief, adiposa, like intima, media, adventitia. Adiposa-derived adipokines - via paracrine way - may contribute to various vascular functions such as contraction-relaxation, smooth muscle cell growth, hemostasis, innervation, and inflammation. Altogether, the concept of tunica adiposa may contribute to further research in cardiovascular adipo-biology in health and disease.

Original languageEnglish
Pages (from-to)46-49
Number of pages4
JournalObesity and Metabolism
Volume6
Issue number2-3
Publication statusPublished - Jun 2010

Fingerprint

Blood Vessels
Adipose Tissue
Adventitia
Atherosclerosis
Adipokines
Hemostasis
Smooth Muscle Myocytes
Inflammation
Health
Wounds and Injuries
Growth
Research
Direction compound

Keywords

  • Adipobiology
  • Adipose tissue
  • Artery
  • Cardiovascular disease

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Internal Medicine

Cite this

Chaldakov, G. N., Fiore, M., Rančić, G., Gehenev, P. I., Tunçel, N., Beltowski, J., ... Aloe, L. (2010). Rethinking vascular wall: Periadventitial adipose tissue (tunica adiposa). Obesity and Metabolism, 6(2-3), 46-49.

Rethinking vascular wall : Periadventitial adipose tissue (tunica adiposa). / Chaldakov, George N.; Fiore, Marco; Rančić, Gorana; Gehenev, Peter I.; Tunçel, Neşe; Beltowski, Jerzy; Hristova, Mariyana G.; Atanassova, Pepa; Aloe, Luigi.

In: Obesity and Metabolism, Vol. 6, No. 2-3, 06.2010, p. 46-49.

Research output: Contribution to journalArticle

Chaldakov, GN, Fiore, M, Rančić, G, Gehenev, PI, Tunçel, N, Beltowski, J, Hristova, MG, Atanassova, P & Aloe, L 2010, 'Rethinking vascular wall: Periadventitial adipose tissue (tunica adiposa)', Obesity and Metabolism, vol. 6, no. 2-3, pp. 46-49.
Chaldakov GN, Fiore M, Rančić G, Gehenev PI, Tunçel N, Beltowski J et al. Rethinking vascular wall: Periadventitial adipose tissue (tunica adiposa). Obesity and Metabolism. 2010 Jun;6(2-3):46-49.
Chaldakov, George N. ; Fiore, Marco ; Rančić, Gorana ; Gehenev, Peter I. ; Tunçel, Neşe ; Beltowski, Jerzy ; Hristova, Mariyana G. ; Atanassova, Pepa ; Aloe, Luigi. / Rethinking vascular wall : Periadventitial adipose tissue (tunica adiposa). In: Obesity and Metabolism. 2010 ; Vol. 6, No. 2-3. pp. 46-49.
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