Reticular erythematous mucinosis: A review of patients' characteristics, associated conditions, therapy and outcome in 25 cases

F. Rongioletti, V. Merlo, S. Riva, E. Cozzani, E. Cinotti, G. Ghigliotti, A. Parodi, J. Kanitakis

Research output: Contribution to journalArticle

Abstract

Background Reticular erythematous mucinosis (REM) is an uncommon disease, the nosology and specific characteristics of which are controversial because most reports deal with single cases or small series. Objectives To describe the characteristics of patients with REM regarding demographics, clinical and pathological features, comorbidities, treatment and course. Methods A retrospective and prospective study was conducted on 25 patients diagnosed with REM in the setting of university-affiliated dermatology departments and dermatopathology centres. Results Of the 25 patients with REM, 16 were women (sex ratio 2: 1) and the mean age was 46 years. The roles of sun exposure and oral contraceptives were ambiguous. Associated diseases included hypertension (n = 4), malignancies (n = 3), autoimmune diseases (n = 3) and Borrelia infection (n = 1). Immunological studies (including serology and direct immunofluorescence) were noncontributory. The response to antimalarial treatment was good in > 80% of cases. Worsening or recurrence of the lesion after treatment discontinuation, or in the course of the disease, occurred in 31% of patients. Conclusions We present the largest REM case series to date. The reticular pattern with involvement of the midline of the chest and back, the predilection for middle-aged women, the controversial relationship with photosensitivity and the possible association with other conditions such as malignancies and thyroid dysfunctions are the main characteristics that makes REM a recognizable disease. What's already known about this topic? Reticular erythematous mucinosis (REM) is an uncommon disease, the nosology and specific characteristics of which are controversial because most reports deal with single cases or small series. What does this study add? We report one of the largest case series of REM to date. We highlight the reticular pattern in REM; the predilection for middle-aged women; the ambiguous role of photosensitivity; the possible association with other conditions such as malignancies and thyroid dysfunctions; and the good response to antimalarials, with possible relapses. Together, these factors make REM a recognizable disease.

Original languageEnglish
Pages (from-to)1207-1211
Number of pages5
JournalBritish Journal of Dermatology
Volume169
Issue number6
DOIs
Publication statusPublished - 2013

Fingerprint

Mucinoses
Therapeutics
Antimalarials
Thyroid Gland
Borrelia Infections
Recurrence
Neoplasms
Direct Fluorescent Antibody Technique
Sex Ratio
Solar System
Serology
Oral Contraceptives
Dermatology
Autoimmune Diseases
Comorbidity
Thorax

ASJC Scopus subject areas

  • Dermatology
  • Medicine(all)

Cite this

Rongioletti, F., Merlo, V., Riva, S., Cozzani, E., Cinotti, E., Ghigliotti, G., ... Kanitakis, J. (2013). Reticular erythematous mucinosis: A review of patients' characteristics, associated conditions, therapy and outcome in 25 cases. British Journal of Dermatology, 169(6), 1207-1211. https://doi.org/10.1111/bjd.12577

Reticular erythematous mucinosis : A review of patients' characteristics, associated conditions, therapy and outcome in 25 cases. / Rongioletti, F.; Merlo, V.; Riva, S.; Cozzani, E.; Cinotti, E.; Ghigliotti, G.; Parodi, A.; Kanitakis, J.

In: British Journal of Dermatology, Vol. 169, No. 6, 2013, p. 1207-1211.

Research output: Contribution to journalArticle

Rongioletti, F. ; Merlo, V. ; Riva, S. ; Cozzani, E. ; Cinotti, E. ; Ghigliotti, G. ; Parodi, A. ; Kanitakis, J. / Reticular erythematous mucinosis : A review of patients' characteristics, associated conditions, therapy and outcome in 25 cases. In: British Journal of Dermatology. 2013 ; Vol. 169, No. 6. pp. 1207-1211.
@article{9728d443454840f38b67bba4a7f52acd,
title = "Reticular erythematous mucinosis: A review of patients' characteristics, associated conditions, therapy and outcome in 25 cases",
abstract = "Background Reticular erythematous mucinosis (REM) is an uncommon disease, the nosology and specific characteristics of which are controversial because most reports deal with single cases or small series. Objectives To describe the characteristics of patients with REM regarding demographics, clinical and pathological features, comorbidities, treatment and course. Methods A retrospective and prospective study was conducted on 25 patients diagnosed with REM in the setting of university-affiliated dermatology departments and dermatopathology centres. Results Of the 25 patients with REM, 16 were women (sex ratio 2: 1) and the mean age was 46 years. The roles of sun exposure and oral contraceptives were ambiguous. Associated diseases included hypertension (n = 4), malignancies (n = 3), autoimmune diseases (n = 3) and Borrelia infection (n = 1). Immunological studies (including serology and direct immunofluorescence) were noncontributory. The response to antimalarial treatment was good in > 80{\%} of cases. Worsening or recurrence of the lesion after treatment discontinuation, or in the course of the disease, occurred in 31{\%} of patients. Conclusions We present the largest REM case series to date. The reticular pattern with involvement of the midline of the chest and back, the predilection for middle-aged women, the controversial relationship with photosensitivity and the possible association with other conditions such as malignancies and thyroid dysfunctions are the main characteristics that makes REM a recognizable disease. What's already known about this topic? Reticular erythematous mucinosis (REM) is an uncommon disease, the nosology and specific characteristics of which are controversial because most reports deal with single cases or small series. What does this study add? We report one of the largest case series of REM to date. We highlight the reticular pattern in REM; the predilection for middle-aged women; the ambiguous role of photosensitivity; the possible association with other conditions such as malignancies and thyroid dysfunctions; and the good response to antimalarials, with possible relapses. Together, these factors make REM a recognizable disease.",
author = "F. Rongioletti and V. Merlo and S. Riva and E. Cozzani and E. Cinotti and G. Ghigliotti and A. Parodi and J. Kanitakis",
year = "2013",
doi = "10.1111/bjd.12577",
language = "English",
volume = "169",
pages = "1207--1211",
journal = "British Journal of Dermatology",
issn = "0007-0963",
publisher = "Blackwell Publishing Ltd",
number = "6",

}

TY - JOUR

T1 - Reticular erythematous mucinosis

T2 - A review of patients' characteristics, associated conditions, therapy and outcome in 25 cases

AU - Rongioletti, F.

AU - Merlo, V.

AU - Riva, S.

AU - Cozzani, E.

AU - Cinotti, E.

AU - Ghigliotti, G.

AU - Parodi, A.

AU - Kanitakis, J.

PY - 2013

Y1 - 2013

N2 - Background Reticular erythematous mucinosis (REM) is an uncommon disease, the nosology and specific characteristics of which are controversial because most reports deal with single cases or small series. Objectives To describe the characteristics of patients with REM regarding demographics, clinical and pathological features, comorbidities, treatment and course. Methods A retrospective and prospective study was conducted on 25 patients diagnosed with REM in the setting of university-affiliated dermatology departments and dermatopathology centres. Results Of the 25 patients with REM, 16 were women (sex ratio 2: 1) and the mean age was 46 years. The roles of sun exposure and oral contraceptives were ambiguous. Associated diseases included hypertension (n = 4), malignancies (n = 3), autoimmune diseases (n = 3) and Borrelia infection (n = 1). Immunological studies (including serology and direct immunofluorescence) were noncontributory. The response to antimalarial treatment was good in > 80% of cases. Worsening or recurrence of the lesion after treatment discontinuation, or in the course of the disease, occurred in 31% of patients. Conclusions We present the largest REM case series to date. The reticular pattern with involvement of the midline of the chest and back, the predilection for middle-aged women, the controversial relationship with photosensitivity and the possible association with other conditions such as malignancies and thyroid dysfunctions are the main characteristics that makes REM a recognizable disease. What's already known about this topic? Reticular erythematous mucinosis (REM) is an uncommon disease, the nosology and specific characteristics of which are controversial because most reports deal with single cases or small series. What does this study add? We report one of the largest case series of REM to date. We highlight the reticular pattern in REM; the predilection for middle-aged women; the ambiguous role of photosensitivity; the possible association with other conditions such as malignancies and thyroid dysfunctions; and the good response to antimalarials, with possible relapses. Together, these factors make REM a recognizable disease.

AB - Background Reticular erythematous mucinosis (REM) is an uncommon disease, the nosology and specific characteristics of which are controversial because most reports deal with single cases or small series. Objectives To describe the characteristics of patients with REM regarding demographics, clinical and pathological features, comorbidities, treatment and course. Methods A retrospective and prospective study was conducted on 25 patients diagnosed with REM in the setting of university-affiliated dermatology departments and dermatopathology centres. Results Of the 25 patients with REM, 16 were women (sex ratio 2: 1) and the mean age was 46 years. The roles of sun exposure and oral contraceptives were ambiguous. Associated diseases included hypertension (n = 4), malignancies (n = 3), autoimmune diseases (n = 3) and Borrelia infection (n = 1). Immunological studies (including serology and direct immunofluorescence) were noncontributory. The response to antimalarial treatment was good in > 80% of cases. Worsening or recurrence of the lesion after treatment discontinuation, or in the course of the disease, occurred in 31% of patients. Conclusions We present the largest REM case series to date. The reticular pattern with involvement of the midline of the chest and back, the predilection for middle-aged women, the controversial relationship with photosensitivity and the possible association with other conditions such as malignancies and thyroid dysfunctions are the main characteristics that makes REM a recognizable disease. What's already known about this topic? Reticular erythematous mucinosis (REM) is an uncommon disease, the nosology and specific characteristics of which are controversial because most reports deal with single cases or small series. What does this study add? We report one of the largest case series of REM to date. We highlight the reticular pattern in REM; the predilection for middle-aged women; the ambiguous role of photosensitivity; the possible association with other conditions such as malignancies and thyroid dysfunctions; and the good response to antimalarials, with possible relapses. Together, these factors make REM a recognizable disease.

UR - http://www.scopus.com/inward/record.url?scp=84889012600&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84889012600&partnerID=8YFLogxK

U2 - 10.1111/bjd.12577

DO - 10.1111/bjd.12577

M3 - Article

C2 - 23937648

AN - SCOPUS:84889012600

VL - 169

SP - 1207

EP - 1211

JO - British Journal of Dermatology

JF - British Journal of Dermatology

SN - 0007-0963

IS - 6

ER -