Reticular erythematous mucinosis

Histopathological and immunohistochemical features of 25 patients compared with 25 cases of lupus erythematosus tumidus

E. Cinotti, V. Merlo, W. Kempf, C. Carli, J. Kanitakis, A. Parodi, F. Rongioletti

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Background and objectives Reticular erythematous mucinosis (REM) and lupus erythematosus tumidus (LET) share similarities. However, to our knowledge no study extensively compared the histological features of these two conditions. The aim of this study is to compare the histological and immunohistochemical features of REM and LET. Methods We evaluated epidermal thickness, hyperkeratosis, dermo-epidermal junction changes, interstitial mucin deposition, vessel dilatation and pattern, type and density of the inflammatory infiltrate in 25 cases of REM and LET. Anti-CD3, anti-CD20, anti-CD68, anti-CD4, anti-CD8, anti-CD123, anti-CD2AP, anti-IgG and anti-C3 antibodies were tested in a subset of patients. Results Both diseases are characterized by perivascular dermal infiltrates of lymphocytes mainly CD4+ positive and increased dermal mucin. However, REM tended to show more scattered and more superficial lymphocytes with more superficial mucin and to have less frequent immunoglobulin and complement depositions along the dermo-epidermal junction. Plasmacytoid dendritic cells (PDCs) were less represented in REM, and were mainly found as single cells differently from LET. Conclusions REM and LET present some differences in the infiltrate, including PDCs, the mucin deposition and the immunoreactant deposition at the dermo-epidermal junction that justify the distinction of the two diseases and suggest different pathogenetic mechanisms.

Original languageEnglish
Pages (from-to)689-697
Number of pages9
JournalJournal of the European Academy of Dermatology and Venereology
Volume29
Issue number4
DOIs
Publication statusPublished - Apr 1 2015

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Mucinoses
Mucins
Dendritic Cells
CD4-Positive T-Lymphocytes
Skin
Immunoglobulins
Dilatation
Anti-Idiotypic Antibodies
Lymphocytes

ASJC Scopus subject areas

  • Dermatology
  • Infectious Diseases
  • Medicine(all)

Cite this

Reticular erythematous mucinosis : Histopathological and immunohistochemical features of 25 patients compared with 25 cases of lupus erythematosus tumidus. / Cinotti, E.; Merlo, V.; Kempf, W.; Carli, C.; Kanitakis, J.; Parodi, A.; Rongioletti, F.

In: Journal of the European Academy of Dermatology and Venereology, Vol. 29, No. 4, 01.04.2015, p. 689-697.

Research output: Contribution to journalArticle

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abstract = "Background and objectives Reticular erythematous mucinosis (REM) and lupus erythematosus tumidus (LET) share similarities. However, to our knowledge no study extensively compared the histological features of these two conditions. The aim of this study is to compare the histological and immunohistochemical features of REM and LET. Methods We evaluated epidermal thickness, hyperkeratosis, dermo-epidermal junction changes, interstitial mucin deposition, vessel dilatation and pattern, type and density of the inflammatory infiltrate in 25 cases of REM and LET. Anti-CD3, anti-CD20, anti-CD68, anti-CD4, anti-CD8, anti-CD123, anti-CD2AP, anti-IgG and anti-C3 antibodies were tested in a subset of patients. Results Both diseases are characterized by perivascular dermal infiltrates of lymphocytes mainly CD4+ positive and increased dermal mucin. However, REM tended to show more scattered and more superficial lymphocytes with more superficial mucin and to have less frequent immunoglobulin and complement depositions along the dermo-epidermal junction. Plasmacytoid dendritic cells (PDCs) were less represented in REM, and were mainly found as single cells differently from LET. Conclusions REM and LET present some differences in the infiltrate, including PDCs, the mucin deposition and the immunoreactant deposition at the dermo-epidermal junction that justify the distinction of the two diseases and suggest different pathogenetic mechanisms.",
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AU - Kempf, W.

AU - Carli, C.

AU - Kanitakis, J.

AU - Parodi, A.

AU - Rongioletti, F.

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