Mucinosi eritematosa reticolare (sindrome REM). Studio di un caso e valutazione della risposta alla terapia con idrossiclorochina

Translated title of the contribution: Reticular erythematous mucinosis syndrome (REM syndrome). Case report and therapeutical response to hydroxychloroquine sulfate

V. Brazzelli, M. G. Chiesa, F. Baldini, C. Vassallo, M. Ardigo, R. Rosso, G. Borroni

Research output: Contribution to journalArticlepeer-review

Abstract

Reticular erythematous mucinosis (REM) syndrome is a rare, chronic disease characterized by asymptomatic, persistent reticular, slightly infiltrated erythematous plaques on chest and/or back with slight infiltration. Mild itching may be associated. At present, almost 100 patients with REM syndrome have been described. The case of a young woman with a pruritic, erythematous, reticular plaque on her back, worsened by sun exposure is described. Clinical and laboratory data were in the normal range or negative, the skin biopsy demonstrated the presence of mucin among collagen bundles and around blood vessels and adnexa; perivascular and periadnexial lymphocytic infiltration was present. Alcian blue pH 2.5 staining was strongly and diffusely positive. Direct immunofluorescence of the skin biopsy revealed the deposition of IgA, IgM, and fibrin around the papillary blood vessels, and complement at the dermoepidermal junction. Electron microscopy showed granular and filamentous material between the collagen fibres. All these features were consistent with a diagnosis of REM. Treatment with hydroxychloroquine sulfate 400 mg/day for a month and successively 200 mg/day, carotenoids and sun-screen creams resulted in a complete resolution of REM lesions. No recurrence of REM was seen at one year follow-up examination.

Translated title of the contributionReticular erythematous mucinosis syndrome (REM syndrome). Case report and therapeutical response to hydroxychloroquine sulfate
Original languageItalian
Pages (from-to)217-221
Number of pages5
JournalGiornale Italiano di Dermatologia e Venereologia
Volume135
Issue number2
Publication statusPublished - 2000

ASJC Scopus subject areas

  • Dermatology

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