Retinal cotton-wool-like spots: a marker for AIDS?

P. P. Pezzi, S. Tamburi, G. P. D'offizi, I. Mezzaroma, F. Aiuti

Research output: Contribution to journalArticlepeer-review


The prognostic value of ocular manifestations and its correlation with immune changes in HIV-infected subjects was studied longitudinally with an average follow-up of one year (3-22 months). The most common ocular manifestations were retinal cotton-wool-like spots, observed in 58.8% of AIDS patients and in 76.9% of those with ocular involvement. Two of three ARC cases with cotton-wool-like spots developed Pneumocystis carinii pneumonia a few weeks after ophthalmoscopic examination. A close correlation between ocular changes and decrease of CD4+ lymphocytes was observed. In our opinion, these ocular manifestations are as useful as opportunistic infections or AIDS-related neoplasias in the natural history of HIV infection.

Original languageEnglish
Pages (from-to)31-33
Number of pages3
JournalAnnals of Ophthalmology
Issue number1
Publication statusPublished - Jan 1989

ASJC Scopus subject areas

  • Medicine(all)


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