Retinal cotton-wool-like spots: A marker for AIDS

P. Pivetti-Pezzi, S. Tamburi, G. P. D'Offizi, I. Mezzaroma, F. Aiuti

Research output: Contribution to journalArticlepeer-review


The prognostic value of ocular manifestations and their correlation with immune changes in HIV-infected subjects (75 PGL, 23 ARC, and 17 AIDS) have been longitudinally studied with an average follow-up of one year (3 to 22 months). The most common ocular manifestations were retinal cotton-wool-like spots, observed in 58.8% of AIDS patients and in 76.9% of those with ocular involvement. Two of three ARC patients who showed cotton-wool-like spots developed PCP a few weeks after ophthalmoscopic examination. A close correlation between ocular changes and decrease of CD4+ lymphocytes was observed. In our opinion, these ocular manifestations are as useful an indicator as opportunistic infections or AIDS-related neoplasias in the prognosis of HIV infection.

Original languageEnglish
Pages (from-to)41-44
Number of pages4
JournalComprehensive Therapy
Issue number3
Publication statusPublished - 1988

ASJC Scopus subject areas

  • Medicine(all)


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