Retinal function in patients with serpiginous choroiditis: A microperimetry study

Elisabetta Pilotto, Stela Vujosevic, Vuga Ana Grgic, Patrik Sportiello, Enrica Convento, Antonio Giovanni Secchi, Edoardo Midena

Research output: Contribution to journalArticlepeer-review


Purpose: To investigate fixation pattern and retinal sensitivity in patients with serpiginous choroiditis (SC). Methods: Twenty-eight eyes (14 patients) with SC were evaluated. Best-corrected visual acuity, color fundus photography, fundus autofluorescence, and fluorescein and indocyanine green angiography were performed. Microperimetry was used to assess fixation pattern and retinal sensitivity. Results: Of 28 eyes, 16 (57%) had central, one (4%) poor central, and 11 (39%) eccentric fixation; and 18 (64%) had stable, four (14%) relatively unstable, and six (21%) unstable fixation. In patients with posterior pole symmetrically involved in both eyes, the better eye had stable and central fixation in all cases. Atrophic lesions were characterized by a dense scotoma in all cases, with a relative scotoma at their margins in ten eyes (38%). In two cases of active disease, a dense scotoma correlated to an active lesion could be detected. A relative scotoma was documented in areas not involved by the disease at the posterior pole in eight eyes (28%), and in the peripapillary area in 11 eyes (39%). Conclusions: Quantification of retinal sensitivity and fixation pattern by microperimetry offers new data about the impact of visual impairment in patients with SC. A reduction of retinal sensitivity in an apparently healthy area suggests a wider functional involvement of the retina, undetectable by morphologic evaluation alone.

Original languageEnglish
Pages (from-to)1331-1337
Number of pages7
JournalGraefe's Archive for Clinical and Experimental Ophthalmology
Issue number9
Publication statusPublished - Sep 2010


  • Indocyanine green angiography
  • Microperimetry
  • Retinal sensitivity
  • Serpiginous choroiditis

ASJC Scopus subject areas

  • Ophthalmology
  • Sensory Systems
  • Cellular and Molecular Neuroscience


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