Retinal functional changes measured by frequency-doubling technology in patients treated with hydroxychloroquine

Lucia Tanga, Marco Centofanti, Francesco Oddone, Mariacristina Parravano, Vincenzo Parisi, Lucia Ziccardi, Barbara Kroegler, Roberto Perricone, Gianluca Manni

Research output: Contribution to journalArticlepeer-review

Abstract

Background: Antimalarial drugs such as chloroquine (CQ) and hydroxychloroquine (HCQ) are mainly used in the treatment of rheumatologic diseases, and their use may be associated with irreversible retinal toxicity. Previous studies indicate early paracentral visual field loss (Humphrey 10-2) in patients taking HCQ″. These paracentral defects appear before changes in other clinical parameters as visual acuity and fundoscopy. The mechanism of CQ toxicity remains unclear. It was reported that toxic doses of CQ administered for as long as 4.5 years to Rhesus monkeys caused an initial dramatic effect on ganglion cells, followed later by photoreceptors and RPE degeneration. The purpose of this study is to explore early retinal functional changes measured by frequency-doubling technology (FDT) in patients treated with hydroxychloroquine (HCQ). Methods: Forty-eight eyes of 48 subjects treated with hydroxychloroquine (HCQ), with no signs of retinal toxicity, and 36 eyes of 36 age and sex-matched healthy subjects were enrolled in this cross-sectional, prospective, observational, case control study. Functional testing included frequency-doubling Humphrey-matrix perimetry (FDP), white-on-white Humphrey visual field perimetry (HFA), using the 24-2 and 10-2 threshold programs, multifocal electroretinogram (mfERG, Veris 4.9) and low contrast sensitivity (CS) measurement. Results: FDP mean deviation (MD) was found to be significantly reduced in HCQ-treated patients compared to controls both in the 24-2 (-1.38±2.41 dB vs 0.21±1.83dB, p

Original languageEnglish
Pages (from-to)715-721
Number of pages7
JournalGraefe's Archive for Clinical and Experimental Ophthalmology
Volume249
Issue number5
DOIs
Publication statusPublished - May 2011

Keywords

  • Frequency doubling perimetry
  • Hydroxychloroquine
  • Retinal toxicity

ASJC Scopus subject areas

  • Ophthalmology
  • Sensory Systems
  • Cellular and Molecular Neuroscience

Fingerprint Dive into the research topics of 'Retinal functional changes measured by frequency-doubling technology in patients treated with hydroxychloroquine'. Together they form a unique fingerprint.

Cite this