TY - JOUR
T1 - Retinal ganglion cells and circadian rhythms in Alzheimer's disease, Parkinson's disease, and beyond
AU - La Morgia, Chiara
AU - Ross-Cisneros, Fred N.
AU - Sadun, Alfredo A.
AU - Carelli, Valerio
N1 - Ricercatori distaccati presso IRCCS a seguito Convenzione esclusiva con Università di Bologna (La Morgia Chiara, Carelli Valerio)
PY - 2017/5/4
Y1 - 2017/5/4
N2 - There is increasing awareness on the role played by circadian rhythm abnormalities in neurodegenerative disorders such as Alzheimer's disease (AD) and Parkinson's disease (PD). The characterization of the circadian dysfunction parallels the mounting evidence that the hallmarks of neurodegeneration also affect the retina and frequently lead to loss of retinal ganglion cells (RGCs) and to different degrees of optic neuropathy. In the RGC population, there is the subgroup of cells intrinsically photosensitive and expressing the photopigment melanopsin [melanopsin-containing retinal ganglion cells (mRGCs)], which are now well known to drive the entrainment of circadian rhythms to the light-dark cycles. Thus, the correlation between the pathological changes affecting the retina and mRGCs with the circadian imbalance in these neurodegenerative diseases is now clearly emerging, pointing to the possibility that these patients might be amenable to and benefit from light therapy. Currently, this connection is better established for AD and PD, but the same scenario may apply to other neurodegenerative disorders, such as Huntington's disease. This review highlights similarities and differences in the retinal/circadian rhythm axis in these neurodegenerative diseases posing a working frame for future studies.
AB - There is increasing awareness on the role played by circadian rhythm abnormalities in neurodegenerative disorders such as Alzheimer's disease (AD) and Parkinson's disease (PD). The characterization of the circadian dysfunction parallels the mounting evidence that the hallmarks of neurodegeneration also affect the retina and frequently lead to loss of retinal ganglion cells (RGCs) and to different degrees of optic neuropathy. In the RGC population, there is the subgroup of cells intrinsically photosensitive and expressing the photopigment melanopsin [melanopsin-containing retinal ganglion cells (mRGCs)], which are now well known to drive the entrainment of circadian rhythms to the light-dark cycles. Thus, the correlation between the pathological changes affecting the retina and mRGCs with the circadian imbalance in these neurodegenerative diseases is now clearly emerging, pointing to the possibility that these patients might be amenable to and benefit from light therapy. Currently, this connection is better established for AD and PD, but the same scenario may apply to other neurodegenerative disorders, such as Huntington's disease. This review highlights similarities and differences in the retinal/circadian rhythm axis in these neurodegenerative diseases posing a working frame for future studies.
KW - Alzheimer's disease
KW - Circadian rhythms
KW - Huntington's disease
KW - Melanopsin
KW - Optic nerve
KW - Parkinson's disease
KW - Retinal ganglion cells
UR - http://www.scopus.com/inward/record.url?scp=85019832368&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85019832368&partnerID=8YFLogxK
U2 - 10.3389/fneur.2017.00162
DO - 10.3389/fneur.2017.00162
M3 - Short survey
C2 - 28522986
AN - SCOPUS:85019832368
VL - 8
SP - 1
EP - 8
JO - Frontiers in Neurology
JF - Frontiers in Neurology
SN - 1664-2295
IS - MAY
M1 - 162
ER -