In a population of diabetic patients was investigated a possible role of plasmatic fibrinogen level and platelet degranulation in the ischaemic-proliferative progression of diabetic retinopathy, as detected by a fluorescein angiography performed after 5 years. Platelet degranulation was initially evaluated by measuring fibronectin and von Willebrand factor in plasma and in platelet samples with an original double-sandwich micro-ELISA method, as described previously. The results show a statistically significant correlation between the mean fibrinogen level in plasma in the evolved cases vs stationary ones (p <0.05). Fibronectin and von Willebrand factor were increased in the initial group with ischaemic retinopathies (preproliferative and proliferative) vs the others but not in the cases of background retinopathies evolved after 5 years.
|Translated title of the contribution||Retinal ischemia and platelet function in diabetic retinopathy|
|Number of pages||8|
|Journal||Annali di Ottalmologia e Clinica Oculistica|
|Publication status||Published - 1995|
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