ISCHEMIA RETINICA E FUNZIONE PIASTRINICA NELLA RETINOPATIA DIABETICA

Translated title of the contribution: Retinal ischemia and platelet function in diabetic retinopathy

G. Vandelli, A. Negri, A. Porta

Research output: Contribution to journalArticle

Abstract

In a population of diabetic patients was investigated a possible role of plasmatic fibrinogen level and platelet degranulation in the ischaemic-proliferative progression of diabetic retinopathy, as detected by a fluorescein angiography performed after 5 years. Platelet degranulation was initially evaluated by measuring fibronectin and von Willebrand factor in plasma and in platelet samples with an original double-sandwich micro-ELISA method, as described previously. The results show a statistically significant correlation between the mean fibrinogen level in plasma in the evolved cases vs stationary ones (p <0.05). Fibronectin and von Willebrand factor were increased in the initial group with ischaemic retinopathies (preproliferative and proliferative) vs the others but not in the cases of background retinopathies evolved after 5 years.

Translated title of the contributionRetinal ischemia and platelet function in diabetic retinopathy
Original languageItalian
Pages (from-to)53-60
Number of pages8
JournalAnnali di Ottalmologia e Clinica Oculistica
Volume121
Issue number1
Publication statusPublished - 1995

ASJC Scopus subject areas

  • Ophthalmology

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