Retinal laser photocoagulation in diabetic patients causes prolactin, growth hormone and cortisol release

A. E. Pontiroli, G. Baio, P. Maffi, U. Menchini, R. Brancato, G. Pozza

Research output: Contribution to journalArticlepeer-review

Abstract

Stress of many kinds (psychological, physical, metabolic) is able to induce endocrine modifications in humans, such as growth hormone (GH), prolactin (PRL), luteinizing hormone (LH), glucagon and cortisol release. Argon laser photocoagulation of the retina (RP), the treatment of choice for diabetic retinopathy, is a painful and stressful maneuvre and represents a direct injury onto a nervous tissue. Therefore it was decided to evaluate the possible endocrine modifications induced by RP in diabetic patients affected by retinopathy. In 19 insulin-dependent diabetic patients (12 men and 7 women), RP induced cortisol release in all cases, GH and PRL release in men, but not in women, and no modification of LH and glucagon plasma levels; in 12 similar patients receiving saline infusions without RP, no endocrine modifications were observed. It is concluded that RP elicits GH, PRL and cortisol release in diabetic patients.

Original languageEnglish
Pages (from-to)389-391
Number of pages3
JournalJournal of Endocrinological Investigation
Volume11
Issue number5
DOIs
Publication statusPublished - 1988

Keywords

  • cortisol
  • diabetes mellitus
  • glucagon
  • growth hormone
  • laser
  • Prolactin
  • retinal photocoagulation
  • retinopathy
  • stress

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism

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