Retinal Vascular Impairment in Best Vitelliform Macular Dystrophy Assessed by Means of Optical Coherence Tomography Angiography

Maurizio Battaglia Parodi, Francesco Romano, Maria Vittoria Cicinelli, Alessandro Rabiolo, Alessandro Arrigo, Luisa Pierro, Pierluigi Iacono, Francesco Bandello

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Purpose: To evaluate vascular abnormalities at superficial (SCP) and deep (DCP) capillary plexuses and choriocapillaris (CC) in patients with Best vitelliform macular dystrophy (BVMD) by means of optical coherence tomography angiography (OCT-A). Design: Cross-sectional case series. Methods: Sixty-six eyes of 33 patients with BVMD (16 male) and 33 controls were consecutively enrolled. Patients were subdivided into classic stages and underwent best-corrected visual acuity (BCVA), fundus autofluorescence and spectral domain-optical coherence tomography, and 4.5 × 4.5-mm swept-source OCT-A. Choroidal neovascularization (CNV) and capillary dilations were qualitatively assessed by 2 masked ophthalmologists. Each OCT-A slab was imported into ImageJ 1.50 and digitally binarized for quantitative analyses. Foveal avascular zone (FAZ) area was measured manually; vessel density was then quantified after the exclusion of the FAZ pixels. Eyes classified as stages 3 and 4 were evaluated together. Results: Nineteen eyes (28.8%) revealed capillary dilations at DCP, 15 of which were in stages 1 and 2. Interestingly, CNV was detected in 24 eyes (36.4%). Quantitative analysis disclosed that stages 3–4 and 5 carry significant impairment at both SCP (P <.0001 and P =.02, respectively) and DCP (P <.0001 and P =.0004, respectively) compared to controls. FAZ area was enlarged at the DCP (P =.001). Only DCP vessel density significantly correlated with the stage and BCVA. Conclusions: Patients with BVMD show significant vascular impairment at both superficial and deep retinal plexuses, correlating with functional outcomes. These findings, especially at DCP, may improve our understanding about the pathogenesis, and may help in predicting BVMD treatment efficacy.

Original languageEnglish
Pages (from-to)61-70
Number of pages10
JournalAmerican Journal of Ophthalmology
Volume187
DOIs
Publication statusPublished - Mar 1 2018

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Vitelliform Macular Dystrophy
Retinal Vessels
Optical Coherence Tomography
Angiography
Choroidal Neovascularization
Visual Acuity
Blood Vessels
Dilatation

ASJC Scopus subject areas

  • Ophthalmology

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Retinal Vascular Impairment in Best Vitelliform Macular Dystrophy Assessed by Means of Optical Coherence Tomography Angiography. / Battaglia Parodi, Maurizio; Romano, Francesco; Cicinelli, Maria Vittoria; Rabiolo, Alessandro; Arrigo, Alessandro; Pierro, Luisa; Iacono, Pierluigi; Bandello, Francesco.

In: American Journal of Ophthalmology, Vol. 187, 01.03.2018, p. 61-70.

Research output: Contribution to journalArticle

Battaglia Parodi, Maurizio ; Romano, Francesco ; Cicinelli, Maria Vittoria ; Rabiolo, Alessandro ; Arrigo, Alessandro ; Pierro, Luisa ; Iacono, Pierluigi ; Bandello, Francesco. / Retinal Vascular Impairment in Best Vitelliform Macular Dystrophy Assessed by Means of Optical Coherence Tomography Angiography. In: American Journal of Ophthalmology. 2018 ; Vol. 187. pp. 61-70.
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abstract = "Purpose: To evaluate vascular abnormalities at superficial (SCP) and deep (DCP) capillary plexuses and choriocapillaris (CC) in patients with Best vitelliform macular dystrophy (BVMD) by means of optical coherence tomography angiography (OCT-A). Design: Cross-sectional case series. Methods: Sixty-six eyes of 33 patients with BVMD (16 male) and 33 controls were consecutively enrolled. Patients were subdivided into classic stages and underwent best-corrected visual acuity (BCVA), fundus autofluorescence and spectral domain-optical coherence tomography, and 4.5 × 4.5-mm swept-source OCT-A. Choroidal neovascularization (CNV) and capillary dilations were qualitatively assessed by 2 masked ophthalmologists. Each OCT-A slab was imported into ImageJ 1.50 and digitally binarized for quantitative analyses. Foveal avascular zone (FAZ) area was measured manually; vessel density was then quantified after the exclusion of the FAZ pixels. Eyes classified as stages 3 and 4 were evaluated together. Results: Nineteen eyes (28.8{\%}) revealed capillary dilations at DCP, 15 of which were in stages 1 and 2. Interestingly, CNV was detected in 24 eyes (36.4{\%}). Quantitative analysis disclosed that stages 3–4 and 5 carry significant impairment at both SCP (P <.0001 and P =.02, respectively) and DCP (P <.0001 and P =.0004, respectively) compared to controls. FAZ area was enlarged at the DCP (P =.001). Only DCP vessel density significantly correlated with the stage and BCVA. Conclusions: Patients with BVMD show significant vascular impairment at both superficial and deep retinal plexuses, correlating with functional outcomes. These findings, especially at DCP, may improve our understanding about the pathogenesis, and may help in predicting BVMD treatment efficacy.",
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AU - Battaglia Parodi, Maurizio

AU - Romano, Francesco

AU - Cicinelli, Maria Vittoria

AU - Rabiolo, Alessandro

AU - Arrigo, Alessandro

AU - Pierro, Luisa

AU - Iacono, Pierluigi

AU - Bandello, Francesco

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N2 - Purpose: To evaluate vascular abnormalities at superficial (SCP) and deep (DCP) capillary plexuses and choriocapillaris (CC) in patients with Best vitelliform macular dystrophy (BVMD) by means of optical coherence tomography angiography (OCT-A). Design: Cross-sectional case series. Methods: Sixty-six eyes of 33 patients with BVMD (16 male) and 33 controls were consecutively enrolled. Patients were subdivided into classic stages and underwent best-corrected visual acuity (BCVA), fundus autofluorescence and spectral domain-optical coherence tomography, and 4.5 × 4.5-mm swept-source OCT-A. Choroidal neovascularization (CNV) and capillary dilations were qualitatively assessed by 2 masked ophthalmologists. Each OCT-A slab was imported into ImageJ 1.50 and digitally binarized for quantitative analyses. Foveal avascular zone (FAZ) area was measured manually; vessel density was then quantified after the exclusion of the FAZ pixels. Eyes classified as stages 3 and 4 were evaluated together. Results: Nineteen eyes (28.8%) revealed capillary dilations at DCP, 15 of which were in stages 1 and 2. Interestingly, CNV was detected in 24 eyes (36.4%). Quantitative analysis disclosed that stages 3–4 and 5 carry significant impairment at both SCP (P <.0001 and P =.02, respectively) and DCP (P <.0001 and P =.0004, respectively) compared to controls. FAZ area was enlarged at the DCP (P =.001). Only DCP vessel density significantly correlated with the stage and BCVA. Conclusions: Patients with BVMD show significant vascular impairment at both superficial and deep retinal plexuses, correlating with functional outcomes. These findings, especially at DCP, may improve our understanding about the pathogenesis, and may help in predicting BVMD treatment efficacy.

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