Retinoblastoma, chromosome abnormalities and oncogene expression

F. Gilbert, V. R. Potluri, M. P. Short, C. L. Kau, F. Lalatta

Research output: Contribution to journalArticlepeer-review

Abstract

Recurrent chromosomal abnormalities in retinoblastomas invlolve numbers 13, 1, and 6, as well as homogeneously staining regions (HSR) and double minutes (DMS). Evidence suggesting that chromosome 13 contains a gene responsible for tumorigenesis has already been presented. We postulate that the genetic changes resulting from abnormalities of chromosomes 1 and 6 and the HSR/DMS provide a selective growth advantage to cells in which they occur. Support for this hypothesis, as it relates to the HSR/DMS and oncogene amplification, is discussed.

Original languageEnglish
Pages (from-to)3-10
Number of pages8
JournalOphthalmic Paediatrics and Genetics
Volume8
Issue number1
Publication statusPublished - 1987

ASJC Scopus subject areas

  • Ophthalmology
  • Pediatrics, Perinatology, and Child Health
  • Genetics(clinical)

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