Recurrent chromosomal abnormalities in retinoblastomas invlolve numbers 13, 1, and 6, as well as homogeneously staining regions (HSR) and double minutes (DMS). Evidence suggesting that chromosome 13 contains a gene responsible for tumorigenesis has already been presented. We postulate that the genetic changes resulting from abnormalities of chromosomes 1 and 6 and the HSR/DMS provide a selective growth advantage to cells in which they occur. Support for this hypothesis, as it relates to the HSR/DMS and oncogene amplification, is discussed.
|Number of pages||8|
|Journal||Ophthalmic Paediatrics and Genetics|
|Publication status||Published - 1987|
ASJC Scopus subject areas
- Pediatrics, Perinatology, and Child Health