Retinoblastoma, chromosome abnormalities and oncogene expression

F. Gilbert, V. R. Potluri, M. P. Short, C. L. Kau, F. Lalatta

Research output: Contribution to journalArticle

Abstract

Recurrent chromosomal abnormalities in retinoblastomas invlolve numbers 13, 1, and 6, as well as homogeneously staining regions (HSR) and double minutes (DMS). Evidence suggesting that chromosome 13 contains a gene responsible for tumorigenesis has already been presented. We postulate that the genetic changes resulting from abnormalities of chromosomes 1 and 6 and the HSR/DMS provide a selective growth advantage to cells in which they occur. Support for this hypothesis, as it relates to the HSR/DMS and oncogene amplification, is discussed.

Original languageEnglish
Pages (from-to)3-10
Number of pages8
JournalOphthalmic Paediatrics and Genetics
Volume8
Issue number1
Publication statusPublished - 1987

ASJC Scopus subject areas

  • Ophthalmology
  • Pediatrics, Perinatology, and Child Health
  • Genetics(clinical)

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  • Cite this

    Gilbert, F., Potluri, V. R., Short, M. P., Kau, C. L., & Lalatta, F. (1987). Retinoblastoma, chromosome abnormalities and oncogene expression. Ophthalmic Paediatrics and Genetics, 8(1), 3-10.