Retinoblastoma, chromosome abnormalities and oncogene expression

F. Gilbert, V. R. Potluri, M. P. Short, C. L. Kau, F. Lalatta

Research output: Contribution to journalArticle


Recurrent chromosomal abnormalities in retinoblastomas involve numbers 13, 1, and 6, as well as homogeneously staining regions (HSR) and double minutes (DMS). Evidence suggesting that chromosome 13 contains a gene responsible for tumorigenesis has already been presented. We postulate that the genetic changes resulting from abnormalities of chromosomes 1 and 6 and the HSR/DMS provide a selective growth advantage to cells in which they occur. Support for this hypothesis, as it relates to the HSR/DMS and oncogene amplification, is discussed.

Original languageEnglish
Pages (from-to)3-10
Number of pages8
JournalOphthalmic Genetics
Issue number1
Publication statusPublished - 1987


  • Chromosome abnormalities
  • Oncogenes
  • Retinoblastoma

ASJC Scopus subject areas

  • Ophthalmology
  • Pediatrics, Perinatology, and Child Health
  • Genetics(clinical)

Fingerprint Dive into the research topics of 'Retinoblastoma, chromosome abnormalities and oncogene expression'. Together they form a unique fingerprint.

  • Cite this