Retinoic acid enhances the growth of only one subpopulation of granulomonocyte precursors

Massimo Aglietla; Wanda Piacibello; Fiorella Sanavio; Antonio Visconli; Felice Gavosto

Retinoic acid enhances the growth of only one subpopulation of granulomonocyte precursors

Massimo Aglietla, Wanda Piacibello, Fiorella Sanavio, Antonio Visconli, Felice Gavosto

Istituto Oncologico Candiolo

Research output: Contribution to journal › Article › peer-review

Abstract

The effect of various concentrations of retinoic acid on the growth of committed granulomonopoietic precursors (CFU-GM) was studied on semisolid agar cultures. Retinoic acid increased the growth of day 14 CFU-GM but had no significant effect on day 7 CFU-GM. Since the latter are believed to represent the progeny of day 14 CFU-GM it is suggested that the effect of retinoic acid is confined to the early stages of granulomonocytic differentiation.

Original language	English
Pages (from-to)	97-99
Number of pages	3
Journal	Acta Haematologica
Volume	71
Issue number	2
Publication status	Published - 1984

Keywords

CFU-GM
Differentation
Granulopoiesis
Leukemia
Retinoic acid

ASJC Scopus subject areas

Hematology

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abstract = "The effect of various concentrations of retinoic acid on the growth of committed granulomonopoietic precursors (CFU-GM) was studied on semisolid agar cultures. Retinoic acid increased the growth of day 14 CFU-GM but had no significant effect on day 7 CFU-GM. Since the latter are believed to represent the progeny of day 14 CFU-GM it is suggested that the effect of retinoic acid is confined to the early stages of granulomonocytic differentiation.",

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AU - Visconli, Antonio

AU - Gavosto, Felice

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