Retinoic acid enhances the growth of only one subpopulation of granulomonocyte precursors

Massimo Aglietla, Wanda Piacibello, Fiorella Sanavio, Antonio Visconli, Felice Gavosto

Research output: Contribution to journalArticlepeer-review

Abstract

The effect of various concentrations of retinoic acid on the growth of committed granulomonopoietic precursors (CFU-GM) was studied on semisolid agar cultures. Retinoic acid increased the growth of day 14 CFU-GM but had no significant effect on day 7 CFU-GM. Since the latter are believed to represent the progeny of day 14 CFU-GM it is suggested that the effect of retinoic acid is confined to the early stages of granulomonocytic differentiation.

Original languageEnglish
Pages (from-to)97-99
Number of pages3
JournalActa Haematologica
Volume71
Issue number2
Publication statusPublished - 1984

Keywords

  • CFU-GM
  • Differentation
  • Granulopoiesis
  • Leukemia
  • Retinoic acid

ASJC Scopus subject areas

  • Hematology

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