Retinoic acid inhibits fibronectin and laminin synthesis and cell migration of human pleural mesothelioma in vitro

Susanna Scarpa, Anna Giuffrida, Camilla Palumbo, Anna Coletti, Maria Grazia Cerrito, Fortunata Vasaturo, Paola Sinibaldi, Lucilla Simonelli, Antonio Procopio, Andrea Modesti

Research output: Contribution to journalArticlepeer-review

Abstract

The effects of retinoic acid (RA) on cell replication, fibronectin and laminin synthesis, integrin expression and haptotactic migration of three mesothelioma cell cultures of different histotype, one epithelioid, one fibromatous and one biphasic, were evaluated. Cell growth was not affected by RA, while RA treatment decreased the synthesis of fibronectin and laminin and inhibited the migration of all three mesotheliomas on substrates of fibronectin and laminin; on the contrary, the expression of some integrins was not significantly modified by RA. These data indicate that RA may lead to a decrease of mesothelioma cell local invasion; this can correlate with a modification induced by RA on mesothelioma tumor progression in vivo.

Original languageEnglish
Pages (from-to)205-209
Number of pages5
JournalOncology Reports
Volume9
Issue number1
Publication statusPublished - Jan 2002

Keywords

  • Fibronectin
  • Haptotaxis
  • Laminin
  • Mesothelioma

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

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