Retinoid X receptors intersect the molecular clockwork in the regulation of liver metabolism

Research output: Contribution to journalShort surveypeer-review

Abstract

Liver metabolic pathways are driven by the biological clock, and appropriate timing of 24-h patterns of metabolic gene expression as well as anabolic/catabolic processes with wake-related activity/feeding and sleep-related resting/fasting cycles preserves hepatic healthiness. The interplay among the liver metabolic pathways and the molecular clockwork is geared by the nuclear receptors, and ligand-dependent transcription factors that gauge the cellular nutritional status and redox balance, bind hormones and metabolites, and modulate the transcription of thousands target genes through their DNA-binding domain. Several nuclear receptors in the liver oscillate with circadian rhythmicity, and among these, the retinoid X receptors play a key role in metabolism regulation, intersecting with the cogs of the molecular clockwork.

Original languageEnglish
Article number24
JournalFrontiers in Endocrinology
Volume8
Issue numberFEB
DOIs
Publication statusPublished - Feb 13 2017

Keywords

  • Circadian
  • Clock
  • Liver
  • Metabolism
  • Rhythm
  • RXR

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism

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