TY - JOUR
T1 - Retinoid X receptors intersect the molecular clockwork in the regulation of liver metabolism
AU - De Cosmo, Salvatore
AU - Mazzoccoli, Gianluigi
PY - 2017/2/13
Y1 - 2017/2/13
N2 - Liver metabolic pathways are driven by the biological clock, and appropriate timing of 24-h patterns of metabolic gene expression as well as anabolic/catabolic processes with wake-related activity/feeding and sleep-related resting/fasting cycles preserves hepatic healthiness. The interplay among the liver metabolic pathways and the molecular clockwork is geared by the nuclear receptors, and ligand-dependent transcription factors that gauge the cellular nutritional status and redox balance, bind hormones and metabolites, and modulate the transcription of thousands target genes through their DNA-binding domain. Several nuclear receptors in the liver oscillate with circadian rhythmicity, and among these, the retinoid X receptors play a key role in metabolism regulation, intersecting with the cogs of the molecular clockwork.
AB - Liver metabolic pathways are driven by the biological clock, and appropriate timing of 24-h patterns of metabolic gene expression as well as anabolic/catabolic processes with wake-related activity/feeding and sleep-related resting/fasting cycles preserves hepatic healthiness. The interplay among the liver metabolic pathways and the molecular clockwork is geared by the nuclear receptors, and ligand-dependent transcription factors that gauge the cellular nutritional status and redox balance, bind hormones and metabolites, and modulate the transcription of thousands target genes through their DNA-binding domain. Several nuclear receptors in the liver oscillate with circadian rhythmicity, and among these, the retinoid X receptors play a key role in metabolism regulation, intersecting with the cogs of the molecular clockwork.
KW - Circadian
KW - Clock
KW - Liver
KW - Metabolism
KW - Rhythm
KW - RXR
UR - http://www.scopus.com/inward/record.url?scp=85014182866&partnerID=8YFLogxK
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U2 - 10.3389/fendo.2017.00024
DO - 10.3389/fendo.2017.00024
M3 - Short survey
AN - SCOPUS:85014182866
VL - 8
JO - Frontiers in Endocrinology
JF - Frontiers in Endocrinology
SN - 1664-2392
IS - FEB
M1 - 24
ER -