Retinoids and breast cancer: new clues to increase their activity and selectivity

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All-trans retinoic acid and derivatives (retinoids) are promising agents in the management of certain hematologic malignancies and solid tumors, including breast cancer. Retinoids are endowed with anti-proliferative, cyto-differentiating and apoptotic effects that are largely mediated by activation of the nuclear hormone retinoic acid receptors RARα, RARβ and RARγ. These are ligand-dependent transcriptional factors controlling the expression of numerous genes. The relative importance of each receptor subtype for the anti-tumor activity of retinoids is largely unknown. Clarification of this point is of fundamental importance for the rational design of retinoid-based therapeutic approaches aimed at controlling a heterogeneous type of tumors, like breast cancer.

Original languageEnglish
Article number111
JournalBreast Cancer Research
Issue number5
Publication statusPublished - Sep 4 2012

ASJC Scopus subject areas

  • Cancer Research
  • Oncology
  • Medicine(all)


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