Abstract
All-trans retinoic acid and derivatives (retinoids) are promising agents in the management of certain hematologic malignancies and solid tumors, including breast cancer. Retinoids are endowed with anti-proliferative, cyto-differentiating and apoptotic effects that are largely mediated by activation of the nuclear hormone retinoic acid receptors RARα, RARβ and RARγ. These are ligand-dependent transcriptional factors controlling the expression of numerous genes. The relative importance of each receptor subtype for the anti-tumor activity of retinoids is largely unknown. Clarification of this point is of fundamental importance for the rational design of retinoid-based therapeutic approaches aimed at controlling a heterogeneous type of tumors, like breast cancer.
Original language | English |
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Article number | 111 |
Journal | Breast Cancer Research |
Volume | 14 |
Issue number | 5 |
DOIs | |
Publication status | Published - Sep 4 2012 |
ASJC Scopus subject areas
- Cancer Research
- Oncology
- Medicine(all)