Retinol-binding protein 4 in neonates born small for gestational age

C. Giacomozzi, P. Ghirri, R. Lapolla, A. Bartoli, G. Scirè, L. Serino, D. Germani, A. Boldrini, S. Cianfarani

Research output: Contribution to journalArticle

Abstract

Background: Retinol-binding protein 4 (RBP4) is an adipocyte-derived 'signal' that may contribute to the pathogenesis of insulin resistance and Type 2 diabetes. The relationship of RBP4 with insulin resistance and metabolic risk in human beings has been the subject of several studies. Subjects born small for gestational age (SGA) are at risk of insulin resistance and Type 2 diabetes. Though RBP4 could represent an early marker of insulin resistance, to date, none have determined RBP4 in SGA children. Aim: Our aim was to measure RBP4 concentrations in cord blood of SGA newborns compared with those in children born with a birth weight appropriate for gestational age (AGA) and to determine whether serum RBP4 levels at birth correlate with insulin sensitivity markers. Subjects and methods: Sixty-four newborns, 17 born SGA (mean gestational age: 36.4±2.1 weeks), and 47 born AGA (mean gestational age: 37.0±3.6 weeks) were studied. The main outcome measures included anthropometry, lipid profile, insulin, homeostasis model assessment, quantitative insulin-sensitivity check index, adiponectin, and RBP4. Results: RBP4 concentrations were significantly reduced in SGA newborns (p

Original languageEnglish
Pages (from-to)218-221
Number of pages4
JournalJournal of Endocrinological Investigation
Volume33
Issue number4
Publication statusPublished - 2010

Fingerprint

Retinol-Binding Proteins
Gestational Age
Newborn Infant
Insulin Resistance
Type 2 Diabetes Mellitus
Anthropometry
Adiponectin
Fetal Blood
Adipocytes
Birth Weight
Homeostasis
Outcome Assessment (Health Care)
Parturition
Insulin
Lipids

Keywords

  • Adipocytokines
  • Adiponectin
  • Insulin sensitivity
  • Retinol-binding protein 4
  • Small for gestatonal age

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology
  • Medicine(all)

Cite this

Giacomozzi, C., Ghirri, P., Lapolla, R., Bartoli, A., Scirè, G., Serino, L., ... Cianfarani, S. (2010). Retinol-binding protein 4 in neonates born small for gestational age. Journal of Endocrinological Investigation, 33(4), 218-221.

Retinol-binding protein 4 in neonates born small for gestational age. / Giacomozzi, C.; Ghirri, P.; Lapolla, R.; Bartoli, A.; Scirè, G.; Serino, L.; Germani, D.; Boldrini, A.; Cianfarani, S.

In: Journal of Endocrinological Investigation, Vol. 33, No. 4, 2010, p. 218-221.

Research output: Contribution to journalArticle

Giacomozzi, C, Ghirri, P, Lapolla, R, Bartoli, A, Scirè, G, Serino, L, Germani, D, Boldrini, A & Cianfarani, S 2010, 'Retinol-binding protein 4 in neonates born small for gestational age', Journal of Endocrinological Investigation, vol. 33, no. 4, pp. 218-221.
Giacomozzi C, Ghirri P, Lapolla R, Bartoli A, Scirè G, Serino L et al. Retinol-binding protein 4 in neonates born small for gestational age. Journal of Endocrinological Investigation. 2010;33(4):218-221.
Giacomozzi, C. ; Ghirri, P. ; Lapolla, R. ; Bartoli, A. ; Scirè, G. ; Serino, L. ; Germani, D. ; Boldrini, A. ; Cianfarani, S. / Retinol-binding protein 4 in neonates born small for gestational age. In: Journal of Endocrinological Investigation. 2010 ; Vol. 33, No. 4. pp. 218-221.
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