Retinopathy during interferon-β treatment for multiple sclerosis: case report and review of the literature

Lorenzo Gaetani, Paola S. Menduno, Francesco Cometa, Maria Di Gregorio, Paola Sarchielli, Carlo Cagini, Paolo Calabresi, Massimiliano Di Filippo

Research output: Contribution to journalArticle

Abstract

The onset of new visual symptoms in patients with multiple sclerosis is often associated with a neuro-ophthalmologic manifestation of the disease. However, other possible differential diagnoses need to be ruled out, including drug-induced retinal side effects. Although uncommon, retinal side effects of interferon-beta formulations may occur, and need to be promptly recognized and treated by neurologists. In this manuscript, we report the case of a 37-year-old woman affected by multiple sclerosis diagnosed with interferon beta-associated retinopathy and we review the literature with regard to the epidemiology, clinical presentation, management and follow-up of interferon beta-associated retinopathy. Interferon-beta induced retinopathy seems to be an uncommon and a dose-related side effect in multiple sclerosis patients. Retinopathy tends to completely resolve after treatment discontinuation. Neurologists must be aware that immune-modulatory drugs, in particular interferon beta, have been reported to cause retinal side effects. In multiple sclerosis patients complaining of new visual symptoms during interferon-beta treatment, it is thus advisable to perform an ophthalmological assessment to rule out and properly manage retinopathy.

Original languageEnglish
Pages (from-to)422-427
Number of pages6
JournalJournal of Neurology
Volume263
Issue number3
DOIs
Publication statusE-pub ahead of print - Aug 21 2015

Keywords

  • Cotton wool spots
  • Interferon beta
  • Multiple sclerosis (MS)
  • Retinal hemorrhages
  • Retinopathy

ASJC Scopus subject areas

  • Clinical Neurology
  • Neurology

Fingerprint Dive into the research topics of 'Retinopathy during interferon-β treatment for multiple sclerosis: case report and review of the literature'. Together they form a unique fingerprint.

  • Cite this

    Gaetani, L., Menduno, P. S., Cometa, F., Di Gregorio, M., Sarchielli, P., Cagini, C., Calabresi, P., & Di Filippo, M. (2015). Retinopathy during interferon-β treatment for multiple sclerosis: case report and review of the literature. Journal of Neurology, 263(3), 422-427. https://doi.org/10.1007/s00415-015-7879-0