Retinopathy of prematurity and antenatal corticosteroids

V. Console, L. Gagliardi, A. De Giorgi, E. De Ponti, G. Di Stefano, M. G. Romeo, A. Senderi, M. DiPietro, F. Pisano, S. Silvano, M. Anghileri, R. Zanini, E. Lanza, N. Pellizzari, A. M. Raimondi, M. L. Brambilla, M. T. Marsili, D. Rosti, M. E. Bettinelli, S. AccertaD. Spinelli, C. Borroni, L. Abbiari, C. Carlevaro, E. Bertazzi, P. Zaramella, S. Perrone, M. A. Didato, A. Gioeli, G. Cascio, M. Scimeni, E. Volante, L. Gambini, F. Neri, A. Maserati, G. Chinco, C. Migliori, P. E. Bianchi, R. Guagliano, C. Romagnoli, F. Gallini, G. Mintcucci, R. Ricci, G. Guala, L. Fogli, G. Anselmetti, M. R. Berti, D. Pedrotti, E. Zampedri, S. De Silva, M. C. Fertz, P. Perissutti

Research output: Contribution to journalArticlepeer-review


Objectives. It is not known whether antenatal corticosteroids (ANS) can reduce the risk of retinopathy of prematurity (ROP). The aim of this study was to evaluate in a prospective cohort study the effect of ANS on ROP development and severity. Methods. All infants consecutively admitted to 14 centres from 1.1.1992 to 31.12.1993, with a gestational age ≤ 30 weeks, no congenital anomalies, and who survived to 6 months, were enrolled (N=380). Mean birth weight of the cohort was 1157 g; mean gestational age was 28.4 weeks. ROP stage 1-2 developed in 82 neonates; ROP stage 3-3+ in 57. Only 70 neonates (18.4%) received ANS prophylaxis. Results. ANS prophylaxis highly significantly reduced the risk of developing ROP [Odds ratio, (OR), 0.35; 95% confidence interval 0.17-0.71, logistic regression analysis], and that of severe (stage 3-3+) ROP (OR 0.07; 95% confidence interval; 0.02-0.34). Short gestation, low birth weight, bronchopulmonary dysplasia also were significantly associated with ROP development and severity; respiratory distress syndrome and not being treated with surfactant were significant risk factors for ROP severity. Conclusions. ANS prophylaxis protected both against ROP development and against severe forms of ROP. Prematurity and respiratory morbidity still represent independent risk factors for ROP.

Original languageEnglish
Pages (from-to)75-79
Number of pages5
JournalActa Biomedica
Issue numberSUPPL. 1
Publication statusPublished - 1997


  • Newborn infant
  • Prophylaxis
  • Retinopathy of prematurity
  • Steroids

ASJC Scopus subject areas

  • Medicine(all)


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