RET/PTC oncogene activation is an early event in thyroid carcinogenesis

G. Viglietto, G. Chiappetta, F. J. Martinez-Tello, F. H. Fukunaga, G. Tallini, D. Rigopoulou, R. Visconti, A. Mastro, M. Santoro, A. Fusco

Research output: Contribution to journalArticlepeer-review

Abstract

RET/PTC oncogene activation occurs in about 20% of human thyroid papillary carcinomas. However, it is not known yet whether it is an early or late event in the process of thyroid carcinogenesis. Here we demonstrate, by using a combined immunohistochemical and reverse-transcriptase-polymerase chain reaction based approach, that RET/PTC activation is present in 11 out of 26 occult thyroid papillary carcinomas analysed. Therefore, we conclude that it represents an early event in the process of thyroid cell transformation.

Original languageEnglish
Pages (from-to)1207-1210
Number of pages4
JournalOncogene
Volume11
Issue number6
Publication statusPublished - 1995

Keywords

  • Occult carcinomas
  • RET proto-oncogene
  • RET/PTC oncogene
  • RT-PCR
  • Thyroid

ASJC Scopus subject areas

  • Cancer Research
  • Genetics
  • Molecular Biology

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