Retrospective study of a large population of patients with asymptomatic or minimally symptomatic raised serum creatine kinase levels

Alessandro Prelle, Lucia Tancredi, Monica Sciacco, Luca Chiveri, Giacomo P. Comi, Alessandro Battistel, Paola Bazzi, Filippo Martinelli Boneschi, Vincenzo Bagnardi, Patrizia Ciscato, Andreina Bordoni, Franco Fortunato, Sandra Strazzer, Nereo Bresolin, Guglielmo Scarlato, Maurizio Moggio

Research output: Contribution to journalArticle

Abstract

A retrospective evaluation of asymptomatic subjects with persistent elevation of serum creatine kinase (CK) levels (hyperCKemia) was made in order to verify the presence of subclinical myopathy or idiopathic hyperCKemia and to define the most appropriate diagnostic pathway. Persistently increased serum CK levels are occasionally encountered in healthy individuals. In 1980 Rowland coined for them the term idiopathic hyperCKemia. Despite the increase of scientific knowledge, several healthy subjects with hyperCKemia still represent a problem for the clinician. We made a retrospective evaluation of 114 asymptomatic or minimally symptomatic individuals with incidentally detected persistent hyperCKemia. They underwent neurological examination and laboratory/instrumental evaluation. Skeletal muscle biopsy was performed and thoroughly investigated. Biochemical and genetic investigations were added in selected cases. Logistic regression analysis was applied. We diagnosed a neuromuscular disorder in 21 patients (18.4%), and found, by muscle biopsy and/or EMG, pathological but not conclusive findings in 57 subjects (50%). The statistic correlation between elevated serum CK levels and the probability of making a diagnosis changed according to the age of the patient. Conclusions: Muscle biopsy is the basic tool for screening asymptomatic subjects with hyperCkemia. It allowed us to make a diagnosis of disease in 18.4% of patients, and to detect skeletal muscle abnormalities in 38.6% of the subjects. Interestingly, 31.6% of individuals had completely normal muscle findings. These best fit the "diagnosis" of idiopathic hyperCKemia.

Original languageEnglish
Pages (from-to)305-311
Number of pages7
JournalJournal of Neurology
Volume249
Issue number3
DOIs
Publication statusPublished - 2002

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Creatine Kinase
Retrospective Studies
Biopsy
Muscles
Skeletal Muscle
Serum
Population
Neurologic Examination
Molecular Biology
Healthy Volunteers
Logistic Models
Regression Analysis

Keywords

  • HyperCKemia
  • Muscle disease
  • Serum creatine kinase

ASJC Scopus subject areas

  • Clinical Neurology
  • Neurology

Cite this

Retrospective study of a large population of patients with asymptomatic or minimally symptomatic raised serum creatine kinase levels. / Prelle, Alessandro; Tancredi, Lucia; Sciacco, Monica; Chiveri, Luca; Comi, Giacomo P.; Battistel, Alessandro; Bazzi, Paola; Boneschi, Filippo Martinelli; Bagnardi, Vincenzo; Ciscato, Patrizia; Bordoni, Andreina; Fortunato, Franco; Strazzer, Sandra; Bresolin, Nereo; Scarlato, Guglielmo; Moggio, Maurizio.

In: Journal of Neurology, Vol. 249, No. 3, 2002, p. 305-311.

Research output: Contribution to journalArticle

Prelle, Alessandro ; Tancredi, Lucia ; Sciacco, Monica ; Chiveri, Luca ; Comi, Giacomo P. ; Battistel, Alessandro ; Bazzi, Paola ; Boneschi, Filippo Martinelli ; Bagnardi, Vincenzo ; Ciscato, Patrizia ; Bordoni, Andreina ; Fortunato, Franco ; Strazzer, Sandra ; Bresolin, Nereo ; Scarlato, Guglielmo ; Moggio, Maurizio. / Retrospective study of a large population of patients with asymptomatic or minimally symptomatic raised serum creatine kinase levels. In: Journal of Neurology. 2002 ; Vol. 249, No. 3. pp. 305-311.
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AU - Tancredi, Lucia

AU - Sciacco, Monica

AU - Chiveri, Luca

AU - Comi, Giacomo P.

AU - Battistel, Alessandro

AU - Bazzi, Paola

AU - Boneschi, Filippo Martinelli

AU - Bagnardi, Vincenzo

AU - Ciscato, Patrizia

AU - Bordoni, Andreina

AU - Fortunato, Franco

AU - Strazzer, Sandra

AU - Bresolin, Nereo

AU - Scarlato, Guglielmo

AU - Moggio, Maurizio

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