Retrospective study of late radiation-induced damages after focal radiotherapy for childhood brain tumors

Claudia Cavatorta, Silvia Meroni, Eros Montin, Maria C. Oprandi, Emilia Pecori, Mara Lecchi, Barbara Diletto, Ombretta Alessandro, Denis Peruzzo, Veronica Biassoni, Elisabetta Schiavello, Marco Bologna, Maura Massimino, Geraldina Poggi, Luca Mainardi, Filippo Arrigoni, Filippo Spreafico, Paolo Verderio, Emanuele Pignoli, Lorenza Gandola

Research output: Contribution to journalArticlepeer-review

Abstract

Purpose To study a robust and reproducible procedure to investigate a relation between focal brain radiotherapy (RT) low doses, neurocognitive impairment and late White Matter and Gray Matter alterations, as shown by Diffusion Tensor Imaging (DTI), in children. Methods and materials Forty-five patients (23 males and 22 females, median age at RT 6.2 years, median age at evaluations 11.1 years) who had received focal RT for brain tumors were recruited for DTI exams and neurocognitive tests. Patients' brains were parceled in 116 regions of interest (ROIs) using an available segmented atlas. After the development of an ad hoc, homemade, multimodal and highly deformable registration framework, we collected mean RT doses and DTI metrics values for each ROI. The pattern of association between cognitive scores or domains and dose or DTI values was assessed in each ROI through both considering and excluding ROIs with mean doses higher than 75% of the prescription. Subsequently, a preliminary threshold value of dose discriminating patients with and without neurocognitive impairment was selected for the most relevant associations. Results The workflow allowed us to identify 10 ROIs where RT dose and DTI metrics were significantly associated with cognitive tests results (p<0.05). In 5/10 ROIs, RT dose and cognitive tests were associated with p<0.01 and preliminary RT threshold dose values, implying a possible cognitive or neuropsychological damage, were calculated. The analysis of domains showed that the most involved one was the "school-related activities". Conclusion This analysis, despite being conducted on a retrospective cohort of children, shows that the identification of critical brain structures and respective radiation dose thresholds is achievable by combining, with appropriate methodological tools, the large amount of data arising from different sources. This supported the design of a prospective study to gain stronger evidence.

Original languageEnglish
Article numbere0247748
JournalPLoS One
Volume16
Issue number2 Feburary
DOIs
Publication statusPublished - Feb 2021

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)
  • General

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