Retrospective study on adjuvant chemotherapy after surgical resection of colorectal cancer metastatic to the liver

N. Donato, C. Dario, S. Giovanni, B. Virgilio, D. P. Paolo, L. Roberto, P. Gianfranco, L. Mario, P. Daniela, T. Angelo, T. Valter, M. Silvia

Research output: Contribution to journalArticle

Abstract

As a means of defining the role of chemotherapy after radical resection of colorectal liver metastases, a follow-up study of consecutive cases referred to three different surgical clinics, between June 1977 and December 1990 was performed. Data were collected from medical records and recorded on standardized forms. Analysis focused on the impact of treatment on survival of the study population by Cox multivariate analysis. One hundred and twenty-four primary colon cancer cases were reviewed and 102 were fully evaluable. Forty of the 102 were given 5 FU based chemotherapy. According to multivariate survival analysis, time to hepatic metastasis (synchronous vs metachronous, RR = 0.41, 95% C.I. = 0.21-0.78; P = 0.007) and sex (female vs male, RR = 0.48, 95% C.I. = 0.25-0.93; P = 0.029) were significantly associated with better survival. The relative risk of dying associated with treatment was 0.53 (95% C.I. = 0.27-1.05; P = 0.0675). This study suggests that chemotherapy may have an impact on survival, although the size of the effect is not precise. Multicentric randomized clinical trials are required to define the risk/benefit profile of adjuvant chemotherapy.

Original languageEnglish
Pages (from-to)454-460
Number of pages7
JournalEuropean Journal of Surgical Oncology
Volume20
Issue number4
Publication statusPublished - 1994

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Adjuvant Chemotherapy
Colorectal Neoplasms
Retrospective Studies
Drug Therapy
Liver
Multivariate Analysis
Neoplasm Metastasis
Survival Analysis
Fluorouracil
Colonic Neoplasms
Medical Records
Randomized Controlled Trials
Therapeutics
Population

Keywords

  • Follow-up study
  • Liver metastases
  • Survival

ASJC Scopus subject areas

  • Oncology
  • Surgery

Cite this

Retrospective study on adjuvant chemotherapy after surgical resection of colorectal cancer metastatic to the liver. / Donato, N.; Dario, C.; Giovanni, S.; Virgilio, B.; Paolo, D. P.; Roberto, L.; Gianfranco, P.; Mario, L.; Daniela, P.; Angelo, T.; Valter, T.; Silvia, M.

In: European Journal of Surgical Oncology, Vol. 20, No. 4, 1994, p. 454-460.

Research output: Contribution to journalArticle

Donato, N, Dario, C, Giovanni, S, Virgilio, B, Paolo, DP, Roberto, L, Gianfranco, P, Mario, L, Daniela, P, Angelo, T, Valter, T & Silvia, M 1994, 'Retrospective study on adjuvant chemotherapy after surgical resection of colorectal cancer metastatic to the liver', European Journal of Surgical Oncology, vol. 20, no. 4, pp. 454-460.
Donato, N. ; Dario, C. ; Giovanni, S. ; Virgilio, B. ; Paolo, D. P. ; Roberto, L. ; Gianfranco, P. ; Mario, L. ; Daniela, P. ; Angelo, T. ; Valter, T. ; Silvia, M. / Retrospective study on adjuvant chemotherapy after surgical resection of colorectal cancer metastatic to the liver. In: European Journal of Surgical Oncology. 1994 ; Vol. 20, No. 4. pp. 454-460.
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AU - Roberto, L.

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