TY - JOUR
T1 - Retrospective study on PET-SPECT imaging in a large cohort of myotonic dystrophy type 1 patients
AU - Romeo, Vincenzo
AU - Pegoraro, E.
AU - Squarzanti, F.
AU - Sorarù, G.
AU - Ferrati, C.
AU - Ermani, M.
AU - Zucchetta, P.
AU - Chierichetti, F.
AU - Angelini, C.
PY - 2010/12
Y1 - 2010/12
N2 - The aim was to study brain involvement in myotonic dystrophy type 1 by single photon emission tomography (SPECT) and positron emission tomography (PET). 58 DM1 patients were subjected to SPECT; 17 to both SPECT and PET. SPECT patients were grouped as 'normally perfused' and 'abnormally perfused'; PET patients as 'normal performers' and 'abnormal performers'. To quantify hypoperfusion and/or hypometabolism, we used a semi-quantitative scale. To localize focal hypoperfusion/hypometabolism, nine cerebral areas of involvement were identified. The Chi-square, Wilcoxon, McNemar tests were used for statistics. SPECT showed abnormalities in 52/58 patients. PET showed an abnormal glucidic uptake in 15/17. Hypoperfusion was mild/moderate in 50/58 patients, mostly involving the left supratentorial areas. Abnormal glucidic uptake was mainly observed in the left frontal lobe. Abnormalities in blood perfusion and/or glucose metabolism are frequent in DM1. These abnormalities involve the left more often than the right hemisphere, the frontal lobe more than other lobes. Such abnormalities are more often cortical than subcortical.
AB - The aim was to study brain involvement in myotonic dystrophy type 1 by single photon emission tomography (SPECT) and positron emission tomography (PET). 58 DM1 patients were subjected to SPECT; 17 to both SPECT and PET. SPECT patients were grouped as 'normally perfused' and 'abnormally perfused'; PET patients as 'normal performers' and 'abnormal performers'. To quantify hypoperfusion and/or hypometabolism, we used a semi-quantitative scale. To localize focal hypoperfusion/hypometabolism, nine cerebral areas of involvement were identified. The Chi-square, Wilcoxon, McNemar tests were used for statistics. SPECT showed abnormalities in 52/58 patients. PET showed an abnormal glucidic uptake in 15/17. Hypoperfusion was mild/moderate in 50/58 patients, mostly involving the left supratentorial areas. Abnormal glucidic uptake was mainly observed in the left frontal lobe. Abnormalities in blood perfusion and/or glucose metabolism are frequent in DM1. These abnormalities involve the left more often than the right hemisphere, the frontal lobe more than other lobes. Such abnormalities are more often cortical than subcortical.
KW - Brain involvement
KW - DM1
KW - Myotonic dystrophy type 1
KW - PET
KW - SPECT
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U2 - 10.1007/s10072-010-0406-2
DO - 10.1007/s10072-010-0406-2
M3 - Article
C2 - 20842397
AN - SCOPUS:78650509568
VL - 31
SP - 757
EP - 763
JO - Neurological Sciences
JF - Neurological Sciences
SN - 1590-1874
IS - 6
ER -