Retrosplenial and hippocampal brain regions in human navigation: Complementary functional contributions to the formation and use of cognitive maps

Giuseppe Iaria, Jen Kai Chen, Cecilia Guariglia, Alain Ptito, Michael Petrides

Research output: Contribution to journalArticle

Abstract

The ability to orientate within familiar environments relies on the formation and use of a mental representation of the environment, namely a cognitive map. Neuropsychological and neuroimaging studies suggest that the retrosplenial and hippocampal brain regions are involved in topographical orientation. We combined functional magnetic resonance imaging with a virtual-reality paradigm to investigate the functional interaction of the hippocampus and retrosplenial cortex during the formation and utilization of cognitive maps by human subjects. We found that the anterior hippocampus is involved during the formation of the cognitive map, while the posterior hippocampus is involved when using it. In conjunction with the hippocampus, the retrosplenial cortex was active during both the formation and the use of the cognitive map. In accordance with earlier studies in non-human animals, these findings suggest that, while navigating within the environment, the retrosplenial cortex complements the hippocampal contribution to topographical orientation by updating the individual's location as the frame of reference changes.

Original languageEnglish
Pages (from-to)890-899
Number of pages10
JournalEuropean Journal of Neuroscience
Volume25
Issue number3
DOIs
Publication statusPublished - Feb 2007

Keywords

  • Hippocampus
  • Learning
  • Memory
  • Neuroimaging
  • Topographical orientation
  • Virtual reality

ASJC Scopus subject areas

  • Neuroscience(all)

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