TY - JOUR
T1 - Retrosplenial and hippocampal brain regions in human navigation
T2 - Complementary functional contributions to the formation and use of cognitive maps
AU - Iaria, Giuseppe
AU - Chen, Jen Kai
AU - Guariglia, Cecilia
AU - Ptito, Alain
AU - Petrides, Michael
PY - 2007/2
Y1 - 2007/2
N2 - The ability to orientate within familiar environments relies on the formation and use of a mental representation of the environment, namely a cognitive map. Neuropsychological and neuroimaging studies suggest that the retrosplenial and hippocampal brain regions are involved in topographical orientation. We combined functional magnetic resonance imaging with a virtual-reality paradigm to investigate the functional interaction of the hippocampus and retrosplenial cortex during the formation and utilization of cognitive maps by human subjects. We found that the anterior hippocampus is involved during the formation of the cognitive map, while the posterior hippocampus is involved when using it. In conjunction with the hippocampus, the retrosplenial cortex was active during both the formation and the use of the cognitive map. In accordance with earlier studies in non-human animals, these findings suggest that, while navigating within the environment, the retrosplenial cortex complements the hippocampal contribution to topographical orientation by updating the individual's location as the frame of reference changes.
AB - The ability to orientate within familiar environments relies on the formation and use of a mental representation of the environment, namely a cognitive map. Neuropsychological and neuroimaging studies suggest that the retrosplenial and hippocampal brain regions are involved in topographical orientation. We combined functional magnetic resonance imaging with a virtual-reality paradigm to investigate the functional interaction of the hippocampus and retrosplenial cortex during the formation and utilization of cognitive maps by human subjects. We found that the anterior hippocampus is involved during the formation of the cognitive map, while the posterior hippocampus is involved when using it. In conjunction with the hippocampus, the retrosplenial cortex was active during both the formation and the use of the cognitive map. In accordance with earlier studies in non-human animals, these findings suggest that, while navigating within the environment, the retrosplenial cortex complements the hippocampal contribution to topographical orientation by updating the individual's location as the frame of reference changes.
KW - Hippocampus
KW - Learning
KW - Memory
KW - Neuroimaging
KW - Topographical orientation
KW - Virtual reality
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U2 - 10.1111/j.1460-9568.2007.05371.x
DO - 10.1111/j.1460-9568.2007.05371.x
M3 - Article
C2 - 17298595
AN - SCOPUS:33847061272
VL - 25
SP - 890
EP - 899
JO - European Journal of Neuroscience
JF - European Journal of Neuroscience
SN - 0953-816X
IS - 3
ER -