Retroviral interference on STAT activation in individuals coinfected with human T cell leukemia virus type 2 and HIV-1

Chiara Bovolenta, Elisabetta Pilotti, Massimiliano Mauri, Barbara Panzeri, Monica Sassi, PierPaolo Dall'Aglio, Umberto Bertazzoni, Guido Poli, Claudio Casoli

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

Human T cell leukemia virus (HTLV) type-2 is a human retrovirus whose infection has not been tightly linked to human diseases. However, the fairly high prevalence of this infection among HIV-1-positive individuals indicates the importance of better understanding the potential interference of HTLV-2 infection on HIV-1 infection and AIDS. We previously demonstrated that one signature of PBMC freshly derived from HIV-1-infected individuals is the constitutive activation of a C-terminal truncated STAT5 (STAT5Δ). Therefore, we analyzed the potential activation of STATs in HTLV-2 monoinfected and HTLV-2/HIV-1 dually infected individuals. We observed that PBMC of HTLV-2-infected individuals do not show STAT activation unless they are cultivated ex vivo, in the absence of any mitogenic stimuli, for at least 8 h. The emergence of STAT activation, namely of STAT1, in culture was mostly related to the secretion of IFN-γ. Of note, this phenomenon is not only a characteristic feature of HTLV-2-infected individuals but also occurred with PBMC of HIV-1+ individuals. Surprisingly, HTLV-2/HIV-1 coinfection resulted in low/absent STAT activation in vivo that paralleled a diminished secretion of IFN-γ after ex vivo cultivation. Our findings indicate that both HTLV-2 and HIV-1 infection prime T lymphocytes for STAT1 activation, but they also highlight an interference exerted by HTLV-2 on HIV-1-induced STAT1 activation. Although the nature of such a phenomenon is unclear at the present, these findings support the hypothesis that HTLV-2 may interfere with HIV-1 infection at multiple levels.

Original languageEnglish
Pages (from-to)4443-4449
Number of pages7
JournalJournal of Immunology
Volume169
Issue number8
Publication statusPublished - Oct 15 2002

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Deltaretrovirus
HIV-1
HIV Infections
Retroviridae Infections
Virus Diseases
Lymphocyte Activation
Coinfection
Acquired Immunodeficiency Syndrome

ASJC Scopus subject areas

  • Immunology

Cite this

Bovolenta, C., Pilotti, E., Mauri, M., Panzeri, B., Sassi, M., Dall'Aglio, P., ... Casoli, C. (2002). Retroviral interference on STAT activation in individuals coinfected with human T cell leukemia virus type 2 and HIV-1. Journal of Immunology, 169(8), 4443-4449.

Retroviral interference on STAT activation in individuals coinfected with human T cell leukemia virus type 2 and HIV-1. / Bovolenta, Chiara; Pilotti, Elisabetta; Mauri, Massimiliano; Panzeri, Barbara; Sassi, Monica; Dall'Aglio, PierPaolo; Bertazzoni, Umberto; Poli, Guido; Casoli, Claudio.

In: Journal of Immunology, Vol. 169, No. 8, 15.10.2002, p. 4443-4449.

Research output: Contribution to journalArticle

Bovolenta, C, Pilotti, E, Mauri, M, Panzeri, B, Sassi, M, Dall'Aglio, P, Bertazzoni, U, Poli, G & Casoli, C 2002, 'Retroviral interference on STAT activation in individuals coinfected with human T cell leukemia virus type 2 and HIV-1', Journal of Immunology, vol. 169, no. 8, pp. 4443-4449.
Bovolenta C, Pilotti E, Mauri M, Panzeri B, Sassi M, Dall'Aglio P et al. Retroviral interference on STAT activation in individuals coinfected with human T cell leukemia virus type 2 and HIV-1. Journal of Immunology. 2002 Oct 15;169(8):4443-4449.
Bovolenta, Chiara ; Pilotti, Elisabetta ; Mauri, Massimiliano ; Panzeri, Barbara ; Sassi, Monica ; Dall'Aglio, PierPaolo ; Bertazzoni, Umberto ; Poli, Guido ; Casoli, Claudio. / Retroviral interference on STAT activation in individuals coinfected with human T cell leukemia virus type 2 and HIV-1. In: Journal of Immunology. 2002 ; Vol. 169, No. 8. pp. 4443-4449.
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