Retroviral vectors for human gene therapy

Research output: Contribution to journalArticlepeer-review

Abstract

Gene therapy is now a rational approach to the treatment of a wide range of diseases, including congenital and acquired genetic disorders. Amongst possible gene delivery systems, retroviral-mediated gene transfer is the most efficient way to stably introduce genes into human somatic cells and has been the most extensively studied. This is reflected in the fact that the large majority of the ongoing gene therapy clinical trials is based on procedures utilizing retroviral vectors for gene transduction. The general features of retroviral vectors and the strategies for the optimization of retroviral-mediated gene transfer are here presented.

Original languageEnglish
Pages (from-to)108-116
Number of pages9
JournalMinerva Biotecnologica
Volume9
Issue number3
Publication statusPublished - Sep 1997

Keywords

  • Gene therapy
  • Genetic vectors
  • Retroviridal genetics

ASJC Scopus subject areas

  • Biotechnology
  • Applied Microbiology and Biotechnology
  • Bioengineering

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