Revascularization of severe hibernating myocardium in the beating heart: Early hemodynamic and metabolic features

Evasio Pasini, Gianna Ferrari, George Cremona, Mario Ferrari

Research output: Contribution to journalArticlepeer-review


Background. We investigated the effects of coronary artery bypass grafting (CABG) without cardiopulmonary bypass (CPB) in selected patients with severe hibernating myocardium. Methods. Twelve patients (EF = 25% ± 0.7%) with reversible ventricuiar dysfunction (from 2.0 ± 0.06 to 1.6 ± 0.05 left ventricular score index by echodobutamine, p <0.01) in the territory of the left anterior descending artery (LAD) have been studied. Revascularization was achieved by anastomosing the left internal mammary artery to the LAD. The ischemic time of LAD was 9.0 ± 0.4 minutes. Results. Left ventricular function increased 6 hours and 48 hours after revascularization (left ventricular stroke work index from 32 ± 1.8 to 42 ± 1.5 and 40 ± 0.6 gxm/m2, respectively: p = 0.0001). During the surgical procedure, the heart did not release lactate or creatine phosphokinase. There were no perioperative deaths or severe complications. Conclusions. Early hemodynamic and metabolic features of CABG without CPB in patients with hibernating myocardium suggest that this procedure is safe and results in a significant improvement of cardiac function without affecting myocardial metabolism.

Original languageEnglish
Pages (from-to)176-179
Number of pages4
JournalAnnals of Thoracic Surgery
Issue number1
Publication statusPublished - 2001

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Surgery


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