Reversal by the selective D-2 dopamine receptor blocker sulpiride of the hypotensive effect of co-dergocrine in elderly hypertensives

C. Lombardi; R. De Cotiis; C. Spedini; C. Missale; M. Memo; P. F. Spano

doi:10.1007/BF00544247

Reversal by the selective D-2 dopamine receptor blocker sulpiride of the hypotensive effect of co-dergocrine in elderly hypertensives

C. Lombardi, R. De Cotiis, C. Spedini, C. Missale, M. Memo, P. F. Spano

Istituto di Neuroriabilitazione Motoria San Camillo

Research output: Contribution to journal › Article › peer-review

Abstract

The aim of the study was to define the role of peripheral dopaminergic mechanisms in the regulation of blood pressure. The data suggest that the hypotensive effect of the dopaminergic agonist co-dergocrine in elderly hypertensive patients is mediated by interaction with peripheral DA-2 receptors, since it was reversed by the selective antagonist sulpiride in a dose that does not significantly cross the blood brain barrier. The findings suggest the possible therapeutic use of dopamine DA-2 agonists in elderly hypertensive patients.

Original language	English
Pages (from-to)	519-521
Number of pages	3
Journal	European Journal of Clinical Pharmacology
Volume	33
Issue number	5
DOIs	https://doi.org/10.1007/BF00544247
Publication status	Published - Sep 1987

Keywords

co-dergocrine
DA-2 receptors
dopamine
hypertension
sulpiride

ASJC Scopus subject areas

Pharmacology, Toxicology and Pharmaceutics(all)
Pharmacology (medical)

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10.1007/BF00544247

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abstract = "The aim of the study was to define the role of peripheral dopaminergic mechanisms in the regulation of blood pressure. The data suggest that the hypotensive effect of the dopaminergic agonist co-dergocrine in elderly hypertensive patients is mediated by interaction with peripheral DA-2 receptors, since it was reversed by the selective antagonist sulpiride in a dose that does not significantly cross the blood brain barrier. The findings suggest the possible therapeutic use of dopamine DA-2 agonists in elderly hypertensive patients.",

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author = "C. Lombardi and {De Cotiis}, R. and C. Spedini and C. Missale and M. Memo and Spano, {P. F.}",

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AU - Lombardi, C.

AU - De Cotiis, R.

AU - Spedini, C.

AU - Missale, C.

AU - Memo, M.

AU - Spano, P. F.

PY - 1987/9

Y1 - 1987/9

N2 - The aim of the study was to define the role of peripheral dopaminergic mechanisms in the regulation of blood pressure. The data suggest that the hypotensive effect of the dopaminergic agonist co-dergocrine in elderly hypertensive patients is mediated by interaction with peripheral DA-2 receptors, since it was reversed by the selective antagonist sulpiride in a dose that does not significantly cross the blood brain barrier. The findings suggest the possible therapeutic use of dopamine DA-2 agonists in elderly hypertensive patients.

AB - The aim of the study was to define the role of peripheral dopaminergic mechanisms in the regulation of blood pressure. The data suggest that the hypotensive effect of the dopaminergic agonist co-dergocrine in elderly hypertensive patients is mediated by interaction with peripheral DA-2 receptors, since it was reversed by the selective antagonist sulpiride in a dose that does not significantly cross the blood brain barrier. The findings suggest the possible therapeutic use of dopamine DA-2 agonists in elderly hypertensive patients.

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KW - DA-2 receptors

KW - dopamine

KW - hypertension

KW - sulpiride

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Reversal by the selective D-2 dopamine receptor blocker sulpiride of the hypotensive effect of co-dergocrine in elderly hypertensives

Abstract

Keywords

ASJC Scopus subject areas

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