Reversal of angiogenic growth factor upregulation by revascularization of lower limb ischemia

P. Porcu, C. Emanueli, M. Kapatsoris, J. Chao, L. Chao, P. Madeddu

Research output: Contribution to journalArticle

Abstract

Background - Tissue kallikrein (tK) and vascular endothelial growth factor (VEGF) are potent angiogenic agents. Upregulation of tK or VEGF was documented in animal models of acute ischemia, yet it remains unknown whether these endothelial cell mitogens are overexpressed in chronic peripheral vascular insufficiency. Methods and Results - Circulating tK and VEGF were measured in 36 patients with symptomatic peripheral vascular disease before and after surgical revascularization. In 6 patients without symptoms at rest, tK was assayed after exercise stress test. VEGF levels fell within the normal range in all patients (96±11 versus 109±13 pg/mL in healthy control subjects, P=NS) and remained unchanged after revascularization. In contrast, tK expression was upregulated in 34 of 36 patients (1107±203 versus 85±10 pg/mL in control subjects, P

Original languageEnglish
Pages (from-to)67-72
Number of pages6
JournalCirculation
Volume105
Issue number1
DOIs
Publication statusPublished - Jan 1 2002

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Keywords

  • Angiogenesis
  • Atherosclerosis
  • Bradykinin
  • Revascularization

ASJC Scopus subject areas

  • Physiology
  • Cardiology and Cardiovascular Medicine

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