Reversal of CSF positivity for JC virus genome by cidofovir in a patient with systemic lupus erythematosus and progressive multifocal leukoencephalopathy

A. Salmaggi, E. Maccagnano, A. Castagna, S. Zeni, F. Fantini, P. Cinque, M. Savoiardo

Research output: Contribution to journalArticle

Abstract

We report the case of a 36-year-old woman affected by systemic lupus erythematosus who developed rapidly progressive multifocal leukoencephalopathy. Cidofovir therapy induced disappearance of JC virus genome from the cerebrospinal fluid and stabilization of the MRI picture. Despite the fatal outcome after a few months of disease, cidofovir treatment deserves further testing as single antiviral therapy in HIV-negative PML patients.

Original languageEnglish
Pages (from-to)17-20
Number of pages4
JournalNeurological Sciences
Volume22
Issue number1
DOIs
Publication statusPublished - Feb 2001

Keywords

  • Cerebrospinal fluid
  • Cidofovir
  • JC virus genome
  • PML
  • SLE

ASJC Scopus subject areas

  • Neuroscience(all)
  • Clinical Neurology

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