Reversal of gastric electrical dysrhythmias by cisapride in children with functional dyspepsia report of three cases

Salvatore Cucchiara, Raffaele Minella, Giuseppe Riezzo, Gianfranco Vallone, Paolo Vallone, Francesco Castellone, Salvatore Auricchio

Research output: Contribution to journalArticlepeer-review

Abstract

Three children (ages 5, 7.6, and 8 years), with recurrent unexplained upper abdominal symptoms such as vomiting, epigastric pain, anorexia, early satiety and without structural or mucosal abnormalities of gastrointestinal tract, underwent electrogastrography (EGG)-recording of gastric electrical activity using cutaneous electrodes positioned on the epigastric region and connected to a recording polygraph. Frequency of EGG signals was analyzed by fast Fourier transform. Significant changes of fasting and fed gastric myoelectrical activity (tachygastria, bradygastria, flatline pattern) were recorded in the three patients; furthermore, gastric emptying (GE) of a solid-liquid mixed meal, measured by ultrasonography, was significantly prolonged in them. A follow-up study was carried out after an eight-week course with oral cisapride: in all patients symptoms improved, GE time normalized, and EGG analysis showed normal electrical rhythm. It is suggested that gastric dysrhythmias can play a pathogenetic role in patients with functional gastrointestinal symptoms and that symptomatic improvement is accompanied by normalization of gastric electrical rhythm.

Original languageEnglish
Pages (from-to)1136-1140
Number of pages5
JournalDigestive Diseases and Sciences
Volume37
Issue number7
DOIs
Publication statusPublished - Jul 1992

Keywords

  • dysrhythmias
  • functional dyspepsia
  • gastric emptying
  • prokinetic drugs

ASJC Scopus subject areas

  • Gastroenterology

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