REVERSAL OF HEPATIC ALPHA-1-ANTITRYPSIN DEPOSITION AFTER PORTACAVAL SHUNT

T. E. Starzl, A. Francavilla, K. A. Porter, S. Iwatsuki

Research output: Contribution to journalArticle

Abstract

End-to-side portacaval shunts were carried out in three children with the liver disease of alpha-1-antitrypsin deficiency and complications of portal hypertension. Their clinical courses have been stable for 31/2 to almost 7 years. Postoperative liver biopsy material from two of the patients showed the typical histopathological changes caused by portal diversion, as well as an apparent reduction in the quantity of alpha-1-antitrypsin particles in the hepatocytes. The metabolic changes caused by portal diversion have apparently created a more favourable equilibrium between the synthesis and excretion of the abnormal alpha-1-antitrypsin.

Original languageEnglish
Pages (from-to)424-426
Number of pages3
JournalLancet
Volume322
Issue number8347
DOIs
Publication statusPublished - Aug 20 1983

ASJC Scopus subject areas

  • Medicine(all)

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    Starzl, T. E., Francavilla, A., Porter, K. A., & Iwatsuki, S. (1983). REVERSAL OF HEPATIC ALPHA-1-ANTITRYPSIN DEPOSITION AFTER PORTACAVAL SHUNT. Lancet, 322(8347), 424-426. https://doi.org/10.1016/S0140-6736(83)90390-2