Abstract
End-to-side portacaval shunts were carried out in three children with the liver disease of alpha-1-antitrypsin deficiency and complications of portal hypertension. Their clinical courses have been stable for 31/2 to almost 7 years. Postoperative liver biopsy material from two of the patients showed the typical histopathological changes caused by portal diversion, as well as an apparent reduction in the quantity of alpha-1-antitrypsin particles in the hepatocytes. The metabolic changes caused by portal diversion have apparently created a more favourable equilibrium between the synthesis and excretion of the abnormal alpha-1-antitrypsin.
Original language | English |
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Pages (from-to) | 424-426 |
Number of pages | 3 |
Journal | Lancet |
Volume | 322 |
Issue number | 8347 |
DOIs | |
Publication status | Published - Aug 20 1983 |
ASJC Scopus subject areas
- Medicine(all)