Reverse immunoediting

When immunity is edited by antigen

Research output: Contribution to journalArticle

Abstract

Immune selective pressure occurring during cancer immunoediting shapes tumor features revealed at clinical presentation. However, in the "Escape" phase, the tumor itself has the chance to influence the immunological response. Therefore, the capacity of the immune response to sculpt the tumor characteristics is only one side of the coin and even the opposite is likely true, i.e. that an antigen can shape the immune response in a sort of "reverse immunoediting".This reciprocal modeling probably occurs continuously, whenever the immune system encounters a tumor/foreign antigen, and can be operative in the pathogen/immune system interplay, thus possibly permeating the protective immunity as a whole. In line with this view, the characterization of a T cell response as well as the design of both active and passive immunotherapy strategies should also take into account all Ag features (type, load and presentation).Overall, we suggest that the "reverse immunoediting" hypothesis could help to dissect the complex interplay between antigens and the immune repertoire, and to improve the outcome of immunotherapeutic approaches, where T cell responses are manipulated and reprogrammed.

Original languageEnglish
Pages (from-to)16-20
Number of pages5
JournalImmunology Letters
Volume175
DOIs
Publication statusPublished - Jul 1 2016

Fingerprint

Immunity
Antigens
Immune System
Tumor Escape
T-Lymphocytes
Active Immunotherapy
Neoplasms
Numismatics
Passive Immunization
Neoplasm Antigens

Keywords

  • Antigen
  • Cancer
  • Immunodominance
  • Immunoediting
  • Immunotherapy
  • Virus

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy

Cite this

Reverse immunoediting : When immunity is edited by antigen. / Merlo, Anna; Dalla Santa, Silvia; Dolcetti, Riccardo; Zanovello, Paola; Rosato, Antonio.

In: Immunology Letters, Vol. 175, 01.07.2016, p. 16-20.

Research output: Contribution to journalArticle

@article{4fbd650a973840daa07a673737ba4dae,
title = "Reverse immunoediting: When immunity is edited by antigen",
abstract = "Immune selective pressure occurring during cancer immunoediting shapes tumor features revealed at clinical presentation. However, in the {"}Escape{"} phase, the tumor itself has the chance to influence the immunological response. Therefore, the capacity of the immune response to sculpt the tumor characteristics is only one side of the coin and even the opposite is likely true, i.e. that an antigen can shape the immune response in a sort of {"}reverse immunoediting{"}.This reciprocal modeling probably occurs continuously, whenever the immune system encounters a tumor/foreign antigen, and can be operative in the pathogen/immune system interplay, thus possibly permeating the protective immunity as a whole. In line with this view, the characterization of a T cell response as well as the design of both active and passive immunotherapy strategies should also take into account all Ag features (type, load and presentation).Overall, we suggest that the {"}reverse immunoediting{"} hypothesis could help to dissect the complex interplay between antigens and the immune repertoire, and to improve the outcome of immunotherapeutic approaches, where T cell responses are manipulated and reprogrammed.",
keywords = "Antigen, Cancer, Immunodominance, Immunoediting, Immunotherapy, Virus",
author = "Anna Merlo and {Dalla Santa}, Silvia and Riccardo Dolcetti and Paola Zanovello and Antonio Rosato",
year = "2016",
month = "7",
day = "1",
doi = "10.1016/j.imlet.2016.04.015",
language = "English",
volume = "175",
pages = "16--20",
journal = "Immunology Letters",
issn = "0165-2478",
publisher = "Elsevier",

}

TY - JOUR

T1 - Reverse immunoediting

T2 - When immunity is edited by antigen

AU - Merlo, Anna

AU - Dalla Santa, Silvia

AU - Dolcetti, Riccardo

AU - Zanovello, Paola

AU - Rosato, Antonio

PY - 2016/7/1

Y1 - 2016/7/1

N2 - Immune selective pressure occurring during cancer immunoediting shapes tumor features revealed at clinical presentation. However, in the "Escape" phase, the tumor itself has the chance to influence the immunological response. Therefore, the capacity of the immune response to sculpt the tumor characteristics is only one side of the coin and even the opposite is likely true, i.e. that an antigen can shape the immune response in a sort of "reverse immunoediting".This reciprocal modeling probably occurs continuously, whenever the immune system encounters a tumor/foreign antigen, and can be operative in the pathogen/immune system interplay, thus possibly permeating the protective immunity as a whole. In line with this view, the characterization of a T cell response as well as the design of both active and passive immunotherapy strategies should also take into account all Ag features (type, load and presentation).Overall, we suggest that the "reverse immunoediting" hypothesis could help to dissect the complex interplay between antigens and the immune repertoire, and to improve the outcome of immunotherapeutic approaches, where T cell responses are manipulated and reprogrammed.

AB - Immune selective pressure occurring during cancer immunoediting shapes tumor features revealed at clinical presentation. However, in the "Escape" phase, the tumor itself has the chance to influence the immunological response. Therefore, the capacity of the immune response to sculpt the tumor characteristics is only one side of the coin and even the opposite is likely true, i.e. that an antigen can shape the immune response in a sort of "reverse immunoediting".This reciprocal modeling probably occurs continuously, whenever the immune system encounters a tumor/foreign antigen, and can be operative in the pathogen/immune system interplay, thus possibly permeating the protective immunity as a whole. In line with this view, the characterization of a T cell response as well as the design of both active and passive immunotherapy strategies should also take into account all Ag features (type, load and presentation).Overall, we suggest that the "reverse immunoediting" hypothesis could help to dissect the complex interplay between antigens and the immune repertoire, and to improve the outcome of immunotherapeutic approaches, where T cell responses are manipulated and reprogrammed.

KW - Antigen

KW - Cancer

KW - Immunodominance

KW - Immunoediting

KW - Immunotherapy

KW - Virus

UR - http://www.scopus.com/inward/record.url?scp=84966351282&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84966351282&partnerID=8YFLogxK

U2 - 10.1016/j.imlet.2016.04.015

DO - 10.1016/j.imlet.2016.04.015

M3 - Article

VL - 175

SP - 16

EP - 20

JO - Immunology Letters

JF - Immunology Letters

SN - 0165-2478

ER -