Abstract
We studied 25 male patients, with coronary artery disease, mean age 56 ± 8 yr. All underwent 201Tl rest-redistribution and resting 99mTc methoxyisobutyl isonitrile (MIBI) cardiac imaging. Regional 201Tl and MIBI uptake were quantitatively analyzed. Regional left ventricular wall motion (WM) was visually assessed on MIBI gated images using a three-point scale (0 = normal, 1 = hypokinetic, 2 = a/dyskinetic). Two patterns of reverse redistribution (RR) were identified: RR-A when 201Tl uptake was normal on rest images and abnormal on redistribution images, and RR-B when 201Tl uptake was abnormal on rest images and a significant decrease in uptake was observed on redistribution images. Of the total 375 myocardial segments analyzed, 229 were classified as normal (NI), 40 as reversible defect (RD), 74 as irreversible defect (ID); 26 showed RR-A while 6 myocardial segments had RR-B. Myocardial segments with RR-A differed from NI in the degree of coronary artery stenosis (81% ± 33% versus 57% ± 39%, respectively, p <0.05), in WM score (1.1 ± 0.7 versus 0.5 ± 0.6, respectively, p <0.01), and in MIBI uptake (81% ± 10% versus 92% ± 9%, respectively, p <0.0001). Moreover, the percent of myocardial segments supplied by a totally occluded coronary artery was significantly higher (p <0.05) in myocardial segments with RR-A (46%) than in NI (22%). Segments with RR-B did not show any significant difference either from RD and ID. These results suggest that myocardial segments with RR-A on resting 201Tl images have impaired function and are supplied by severely stenosed coronary arteries and should not be considered normal.
| Original language | English |
|---|---|
| Pages (from-to) | 1688-1692 |
| Number of pages | 5 |
| Journal | Journal of Nuclear Medicine |
| Volume | 34 |
| Issue number | 10 |
| Publication status | Published - 1993 |
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ASJC Scopus subject areas
- Radiological and Ultrasound Technology
Cite this
Reverse redistribution in resting thallium-201 myocardial scintigraphy in patients with coronary artery disease : Relation to coronary anatomy and ventricular function. / Pace, L.; Cuocolo, A.; Maurea, S.; Nicolai, E.; Imbriaco, M.; Nappi, A.; Morisco, C.; Chiariello, M.; Trimarco, B.; Salvatore, M.
In: Journal of Nuclear Medicine, Vol. 34, No. 10, 1993, p. 1688-1692.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Reverse redistribution in resting thallium-201 myocardial scintigraphy in patients with coronary artery disease
T2 - Relation to coronary anatomy and ventricular function
AU - Pace, L.
AU - Cuocolo, A.
AU - Maurea, S.
AU - Nicolai, E.
AU - Imbriaco, M.
AU - Nappi, A.
AU - Morisco, C.
AU - Chiariello, M.
AU - Trimarco, B.
AU - Salvatore, M.
PY - 1993
Y1 - 1993
N2 - We studied 25 male patients, with coronary artery disease, mean age 56 ± 8 yr. All underwent 201Tl rest-redistribution and resting 99mTc methoxyisobutyl isonitrile (MIBI) cardiac imaging. Regional 201Tl and MIBI uptake were quantitatively analyzed. Regional left ventricular wall motion (WM) was visually assessed on MIBI gated images using a three-point scale (0 = normal, 1 = hypokinetic, 2 = a/dyskinetic). Two patterns of reverse redistribution (RR) were identified: RR-A when 201Tl uptake was normal on rest images and abnormal on redistribution images, and RR-B when 201Tl uptake was abnormal on rest images and a significant decrease in uptake was observed on redistribution images. Of the total 375 myocardial segments analyzed, 229 were classified as normal (NI), 40 as reversible defect (RD), 74 as irreversible defect (ID); 26 showed RR-A while 6 myocardial segments had RR-B. Myocardial segments with RR-A differed from NI in the degree of coronary artery stenosis (81% ± 33% versus 57% ± 39%, respectively, p <0.05), in WM score (1.1 ± 0.7 versus 0.5 ± 0.6, respectively, p <0.01), and in MIBI uptake (81% ± 10% versus 92% ± 9%, respectively, p <0.0001). Moreover, the percent of myocardial segments supplied by a totally occluded coronary artery was significantly higher (p <0.05) in myocardial segments with RR-A (46%) than in NI (22%). Segments with RR-B did not show any significant difference either from RD and ID. These results suggest that myocardial segments with RR-A on resting 201Tl images have impaired function and are supplied by severely stenosed coronary arteries and should not be considered normal.
AB - We studied 25 male patients, with coronary artery disease, mean age 56 ± 8 yr. All underwent 201Tl rest-redistribution and resting 99mTc methoxyisobutyl isonitrile (MIBI) cardiac imaging. Regional 201Tl and MIBI uptake were quantitatively analyzed. Regional left ventricular wall motion (WM) was visually assessed on MIBI gated images using a three-point scale (0 = normal, 1 = hypokinetic, 2 = a/dyskinetic). Two patterns of reverse redistribution (RR) were identified: RR-A when 201Tl uptake was normal on rest images and abnormal on redistribution images, and RR-B when 201Tl uptake was abnormal on rest images and a significant decrease in uptake was observed on redistribution images. Of the total 375 myocardial segments analyzed, 229 were classified as normal (NI), 40 as reversible defect (RD), 74 as irreversible defect (ID); 26 showed RR-A while 6 myocardial segments had RR-B. Myocardial segments with RR-A differed from NI in the degree of coronary artery stenosis (81% ± 33% versus 57% ± 39%, respectively, p <0.05), in WM score (1.1 ± 0.7 versus 0.5 ± 0.6, respectively, p <0.01), and in MIBI uptake (81% ± 10% versus 92% ± 9%, respectively, p <0.0001). Moreover, the percent of myocardial segments supplied by a totally occluded coronary artery was significantly higher (p <0.05) in myocardial segments with RR-A (46%) than in NI (22%). Segments with RR-B did not show any significant difference either from RD and ID. These results suggest that myocardial segments with RR-A on resting 201Tl images have impaired function and are supplied by severely stenosed coronary arteries and should not be considered normal.
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M3 - Article
C2 - 8410282
AN - SCOPUS:0027484240
VL - 34
SP - 1688
EP - 1692
JO - Journal of Nuclear Medicine
JF - Journal of Nuclear Medicine
SN - 0161-5505
IS - 10
ER -