Reversibility of age associated NK defect by endocrinological and/or nutritional intervention.

M. Provinciali, C. Pieri, N. Fabris

Research output: Contribution to journalArticlepeer-review


Several abnormalities arise at the level of NK cell function in both rodents and humans with increasing age. The age-related changes are not irreversible alterations since they can be reversed either by endocrinological or nutritional approaches, suggesting that age-related microenvironmental changes may play a relevant role in the age-related immune deterioration. Whether endocrine and nutritional factors have an additive effect or act through the same intracellular mechanisms remains to be established, though the first possibility seems more likely since the action of TSH and thyroid hormones is specifically directed towards lymphokine-boosted NK activity, while AL are able to prevent age-associated defect of basal NK cytotoxicity.

Original languageEnglish
Pages (from-to)61-66
Number of pages6
JournalAnnali dell'Istituto Superiore di Sanita
Issue number1
Publication statusPublished - 1991

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health


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