We have previously demonstrated that the cytotoxic activity of spleen cells from Balb/c mice undergoes, during aging, to a progressive decline. In this paper we have evaluated the possibility to recover the age-associated NK defect by means of endocrine or nutritional manipulation. Both thyroxine (T4) and triiodothyronine (T3) plasma levels decline progressively during aging. 'In vivo' T4 administration to old mice causes a significant increment of endogenous NK activity which approaches the values observed in young animals. When T4 is administered 'in vitro' alone or in combination with IFN or IL-2, no effect is observed either on basal or IL-2 induced cytotoxicity whereas the IFN-sensitivity of spleen cells is significantly recovered in old mice and is further increased in old animals. When spleen cells from old mice are incubated 'in vitro' with Active Lipids (AL721) a significant increase in cytotoxic activity is obtained over control cultures. In conclusion, our findings show that the age-related changes of NK cell function are not irreversible alterations since they can be reversed by endocrinological or nutritional approaches.
|Translated title of the contribution||Reversibility of age-associated NK defect by endocrinological or nutritional intervention|
|Number of pages||6|
|Publication status||Published - 1990|
ASJC Scopus subject areas
- Geriatrics and Gerontology