Reversible aphasic disorder induced by lamotrigine in atypical benign childhood epilepsy

Domenica Battaglia, Laura Iuvone, Maria Chiara Stefanini, Celeste Acquafondata, Donatella Lettori, Francesca Chiricozzi, Marika Pane, Antonio Mittica, Francesco Guzzetta

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Purpose: We studied an eleven year-old girl with atypical, benign partial epilepsy who acutely presented a severe aphasia associated with marked EEG deterioration after lamotrigine administration. A parallel monitoring of language disorders and EEG changes during the gradual withdrawal of lamotrigine was performed in order to evaluate their possible correlation with lamotrigine administration. Methods: Detailed neuropsychological and linguistic examinations in association with awake and sleep EEG were periodically performed. Results: The evolution of the aphasic disorder was closely related to the EEG abnormalities, and disappeared after the withdrawal of lamotrigine. Conclusions: We considered the hypothesis that our case could be an expression of a paradoxical reaction to lamotrigine, in which the transitory aphasic disorder was sustained by an epileptiform electric activation.

Original languageEnglish
Pages (from-to)217-222
Number of pages6
JournalEpileptic Disorders
Volume3
Issue number4
Publication statusPublished - 2001

Fingerprint

Epilepsy
Electroencephalography
Language Disorders
Partial Epilepsy
Aphasia
Linguistics
Sleep
lamotrigine

Keywords

  • Adverse drug reaction
  • Childhood epilepsy
  • Lamotrigine
  • Language disorders

ASJC Scopus subject areas

  • Clinical Neurology

Cite this

Battaglia, D., Iuvone, L., Stefanini, M. C., Acquafondata, C., Lettori, D., Chiricozzi, F., ... Guzzetta, F. (2001). Reversible aphasic disorder induced by lamotrigine in atypical benign childhood epilepsy. Epileptic Disorders, 3(4), 217-222.

Reversible aphasic disorder induced by lamotrigine in atypical benign childhood epilepsy. / Battaglia, Domenica; Iuvone, Laura; Stefanini, Maria Chiara; Acquafondata, Celeste; Lettori, Donatella; Chiricozzi, Francesca; Pane, Marika; Mittica, Antonio; Guzzetta, Francesco.

In: Epileptic Disorders, Vol. 3, No. 4, 2001, p. 217-222.

Research output: Contribution to journalArticle

Battaglia, D, Iuvone, L, Stefanini, MC, Acquafondata, C, Lettori, D, Chiricozzi, F, Pane, M, Mittica, A & Guzzetta, F 2001, 'Reversible aphasic disorder induced by lamotrigine in atypical benign childhood epilepsy', Epileptic Disorders, vol. 3, no. 4, pp. 217-222.
Battaglia D, Iuvone L, Stefanini MC, Acquafondata C, Lettori D, Chiricozzi F et al. Reversible aphasic disorder induced by lamotrigine in atypical benign childhood epilepsy. Epileptic Disorders. 2001;3(4):217-222.
Battaglia, Domenica ; Iuvone, Laura ; Stefanini, Maria Chiara ; Acquafondata, Celeste ; Lettori, Donatella ; Chiricozzi, Francesca ; Pane, Marika ; Mittica, Antonio ; Guzzetta, Francesco. / Reversible aphasic disorder induced by lamotrigine in atypical benign childhood epilepsy. In: Epileptic Disorders. 2001 ; Vol. 3, No. 4. pp. 217-222.
@article{f247df8eb4b04f6ba0e591bc049e43f8,
title = "Reversible aphasic disorder induced by lamotrigine in atypical benign childhood epilepsy",
abstract = "Purpose: We studied an eleven year-old girl with atypical, benign partial epilepsy who acutely presented a severe aphasia associated with marked EEG deterioration after lamotrigine administration. A parallel monitoring of language disorders and EEG changes during the gradual withdrawal of lamotrigine was performed in order to evaluate their possible correlation with lamotrigine administration. Methods: Detailed neuropsychological and linguistic examinations in association with awake and sleep EEG were periodically performed. Results: The evolution of the aphasic disorder was closely related to the EEG abnormalities, and disappeared after the withdrawal of lamotrigine. Conclusions: We considered the hypothesis that our case could be an expression of a paradoxical reaction to lamotrigine, in which the transitory aphasic disorder was sustained by an epileptiform electric activation.",
keywords = "Adverse drug reaction, Childhood epilepsy, Lamotrigine, Language disorders",
author = "Domenica Battaglia and Laura Iuvone and Stefanini, {Maria Chiara} and Celeste Acquafondata and Donatella Lettori and Francesca Chiricozzi and Marika Pane and Antonio Mittica and Francesco Guzzetta",
year = "2001",
language = "English",
volume = "3",
pages = "217--222",
journal = "Epileptic Disorders",
issn = "1294-9361",
publisher = "Springer Paris",
number = "4",

}

TY - JOUR

T1 - Reversible aphasic disorder induced by lamotrigine in atypical benign childhood epilepsy

AU - Battaglia, Domenica

AU - Iuvone, Laura

AU - Stefanini, Maria Chiara

AU - Acquafondata, Celeste

AU - Lettori, Donatella

AU - Chiricozzi, Francesca

AU - Pane, Marika

AU - Mittica, Antonio

AU - Guzzetta, Francesco

PY - 2001

Y1 - 2001

N2 - Purpose: We studied an eleven year-old girl with atypical, benign partial epilepsy who acutely presented a severe aphasia associated with marked EEG deterioration after lamotrigine administration. A parallel monitoring of language disorders and EEG changes during the gradual withdrawal of lamotrigine was performed in order to evaluate their possible correlation with lamotrigine administration. Methods: Detailed neuropsychological and linguistic examinations in association with awake and sleep EEG were periodically performed. Results: The evolution of the aphasic disorder was closely related to the EEG abnormalities, and disappeared after the withdrawal of lamotrigine. Conclusions: We considered the hypothesis that our case could be an expression of a paradoxical reaction to lamotrigine, in which the transitory aphasic disorder was sustained by an epileptiform electric activation.

AB - Purpose: We studied an eleven year-old girl with atypical, benign partial epilepsy who acutely presented a severe aphasia associated with marked EEG deterioration after lamotrigine administration. A parallel monitoring of language disorders and EEG changes during the gradual withdrawal of lamotrigine was performed in order to evaluate their possible correlation with lamotrigine administration. Methods: Detailed neuropsychological and linguistic examinations in association with awake and sleep EEG were periodically performed. Results: The evolution of the aphasic disorder was closely related to the EEG abnormalities, and disappeared after the withdrawal of lamotrigine. Conclusions: We considered the hypothesis that our case could be an expression of a paradoxical reaction to lamotrigine, in which the transitory aphasic disorder was sustained by an epileptiform electric activation.

KW - Adverse drug reaction

KW - Childhood epilepsy

KW - Lamotrigine

KW - Language disorders

UR - http://www.scopus.com/inward/record.url?scp=0035716290&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0035716290&partnerID=8YFLogxK

M3 - Article

VL - 3

SP - 217

EP - 222

JO - Epileptic Disorders

JF - Epileptic Disorders

SN - 1294-9361

IS - 4

ER -