Reversible Cognitive Frailty, Dementia, and All-Cause Mortality. The Italian Longitudinal Study on Aging

Vincenzo Solfrizzi; Emanuele Scafato; Davide Seripa; Madia Lozupone; Bruno P. Imbimbo; Angela D'Amato; Rosanna Tortelli; Andrea Schilardi; Lucia Galluzzo; Claudia Gandin; Marzia Baldereschi; Antonio Di Carlo; Domenico Inzitari; Antonio Daniele; Carlo Sabbà; Giancarlo Logroscino; Francesco Panza; Francesco Cacciatore; Franco Rengo; Italian Longitudinal Study on Aging Working Group

doi:10.1016/j.jamda.2016.10.012

Reversible Cognitive Frailty, Dementia, and All-Cause Mortality. The Italian Longitudinal Study on Aging

Vincenzo Solfrizzi, Emanuele Scafato, Davide Seripa, Madia Lozupone, Bruno P. Imbimbo, Angela D'Amato, Rosanna Tortelli, Andrea Schilardi, Lucia Galluzzo, Claudia Gandin, Marzia Baldereschi, Antonio Di Carlo, Domenico Inzitari, Antonio Daniele, Carlo Sabbà, Giancarlo Logroscino, Francesco Panza, Francesco Cacciatore, Franco Rengo, Italian Longitudinal Study on Aging Working Group

Research output: Contribution to journal › Article › peer-review

Abstract

OBJECTIVES: Cognitive frailty, a condition describing the simultaneous presence of physical frailty and mild cognitive impairment, has been recently defined by an international consensus group. We estimated the predictive role of a "reversible" cognitive frailty model on incident dementia, its subtypes, and all-cause mortality in nondemented older individuals. We verified if vascular risk factors or depressive symptoms could modify this predictive role.

DESIGN: Longitudinal population-based study with 3.5- and 7-year of median follow-up.

SETTING: Eight Italian municipalities included in the Italian Longitudinal Study on Aging.

PARTICIPANTS: In 2150 older individuals from the Italian Longitudinal Study on Aging, we operationalized reversible cognitive frailty with the presence of physical frailty and pre-mild cognitive impairment subjective cognitive decline, diagnosed with a self-report measure based on item 14 of the Geriatric Depression Scale.

MEASUREMENTS: Incidence of dementia, its subtypes, and all-cause mortality.

RESULTS: Over a 3.5-year follow-up, participants with reversible cognitive frailty showed an increased risk of overall dementia [hazard ratio (HR) 2.30, 95% confidence interval (CI) 1.02-5.18], particularly vascular dementia (VaD), and all-cause mortality (HR 1.74, 95% CI 1.07-2.83). Over a 7-year follow-up, participants with reversible cognitive frailty showed an increased risk of overall dementia (HR 2.12, 95% CI 1.12-4.03), particularly VaD, and all-cause mortality (HR 1.39, 95% CI 1.03-2.00). Vascular risk factors and depressive symptoms did not have any effect modifier on the relationship between reversible cognitive frailty and incident dementia and all-cause mortality.

CONCLUSIONS: A model of reversible cognitive frailty was a short- and long-term predictor of all-cause mortality and overall dementia, particularly VaD. The absence of vascular risk factors and depressive symptoms did not modify the predictive role of reversible cognitive frailty on these outcomes.

Original language	English
Pages (from-to)	89.e1-89.e8
Journal	Journal of the American Medical Directors Association
Volume	18
Issue number	1
DOIs	https://doi.org/10.1016/j.jamda.2016.10.012
Publication status	Published - Jan 2017

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Journal Article

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Solfrizzi, V., Scafato, E., Seripa, D., Lozupone, M., Imbimbo, B. P., D'Amato, A., Tortelli, R., Schilardi, A., Galluzzo, L., Gandin, C., Baldereschi, M., Di Carlo, A., Inzitari, D., Daniele, A., Sabbà, C., Logroscino, G., Panza, F., Cacciatore, F., Rengo, F., & Italian Longitudinal Study on Aging Working Group (2017). Reversible Cognitive Frailty, Dementia, and All-Cause Mortality. The Italian Longitudinal Study on Aging. Journal of the American Medical Directors Association, 18(1), 89.e1-89.e8. https://doi.org/10.1016/j.jamda.2016.10.012

Reversible Cognitive Frailty, Dementia, and All-Cause Mortality. The Italian Longitudinal Study on Aging. / Solfrizzi, Vincenzo; Scafato, Emanuele; Seripa, Davide; Lozupone, Madia; Imbimbo, Bruno P.; D'Amato, Angela; Tortelli, Rosanna; Schilardi, Andrea; Galluzzo, Lucia; Gandin, Claudia; Baldereschi, Marzia; Di Carlo, Antonio; Inzitari, Domenico; Daniele, Antonio; Sabbà, Carlo; Logroscino, Giancarlo; Panza, Francesco; Cacciatore, Francesco; Rengo, Franco; Italian Longitudinal Study on Aging Working Group.

In: Journal of the American Medical Directors Association, Vol. 18, No. 1, 01.2017, p. 89.e1-89.e8.

Research output: Contribution to journal › Article › peer-review

Solfrizzi, V, Scafato, E, Seripa, D, Lozupone, M, Imbimbo, BP, D'Amato, A, Tortelli, R, Schilardi, A, Galluzzo, L, Gandin, C, Baldereschi, M, Di Carlo, A, Inzitari, D, Daniele, A, Sabbà, C, Logroscino, G, Panza, F, Cacciatore, F, Rengo, F & Italian Longitudinal Study on Aging Working Group 2017, 'Reversible Cognitive Frailty, Dementia, and All-Cause Mortality. The Italian Longitudinal Study on Aging', Journal of the American Medical Directors Association, vol. 18, no. 1, pp. 89.e1-89.e8. https://doi.org/10.1016/j.jamda.2016.10.012

Solfrizzi, Vincenzo ; Scafato, Emanuele ; Seripa, Davide ; Lozupone, Madia ; Imbimbo, Bruno P. ; D'Amato, Angela ; Tortelli, Rosanna ; Schilardi, Andrea ; Galluzzo, Lucia ; Gandin, Claudia ; Baldereschi, Marzia ; Di Carlo, Antonio ; Inzitari, Domenico ; Daniele, Antonio ; Sabbà, Carlo ; Logroscino, Giancarlo ; Panza, Francesco ; Cacciatore, Francesco ; Rengo, Franco ; Italian Longitudinal Study on Aging Working Group. / Reversible Cognitive Frailty, Dementia, and All-Cause Mortality. The Italian Longitudinal Study on Aging. In: Journal of the American Medical Directors Association. 2017 ; Vol. 18, No. 1. pp. 89.e1-89.e8.

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T1 - Reversible Cognitive Frailty, Dementia, and All-Cause Mortality. The Italian Longitudinal Study on Aging

AU - Solfrizzi, Vincenzo

AU - Scafato, Emanuele

AU - Seripa, Davide

AU - Lozupone, Madia

AU - Imbimbo, Bruno P.

AU - D'Amato, Angela

AU - Tortelli, Rosanna

AU - Schilardi, Andrea

AU - Galluzzo, Lucia

AU - Gandin, Claudia

AU - Baldereschi, Marzia

AU - Di Carlo, Antonio

AU - Inzitari, Domenico

AU - Daniele, Antonio

AU - Sabbà, Carlo

AU - Logroscino, Giancarlo

AU - Panza, Francesco

AU - Cacciatore, Francesco

AU - Rengo, Franco

AU - Italian Longitudinal Study on Aging Working Group

PY - 2017/1

Y1 - 2017/1

N2 - OBJECTIVES: Cognitive frailty, a condition describing the simultaneous presence of physical frailty and mild cognitive impairment, has been recently defined by an international consensus group. We estimated the predictive role of a "reversible" cognitive frailty model on incident dementia, its subtypes, and all-cause mortality in nondemented older individuals. We verified if vascular risk factors or depressive symptoms could modify this predictive role.DESIGN: Longitudinal population-based study with 3.5- and 7-year of median follow-up.SETTING: Eight Italian municipalities included in the Italian Longitudinal Study on Aging.PARTICIPANTS: In 2150 older individuals from the Italian Longitudinal Study on Aging, we operationalized reversible cognitive frailty with the presence of physical frailty and pre-mild cognitive impairment subjective cognitive decline, diagnosed with a self-report measure based on item 14 of the Geriatric Depression Scale.MEASUREMENTS: Incidence of dementia, its subtypes, and all-cause mortality.RESULTS: Over a 3.5-year follow-up, participants with reversible cognitive frailty showed an increased risk of overall dementia [hazard ratio (HR) 2.30, 95% confidence interval (CI) 1.02-5.18], particularly vascular dementia (VaD), and all-cause mortality (HR 1.74, 95% CI 1.07-2.83). Over a 7-year follow-up, participants with reversible cognitive frailty showed an increased risk of overall dementia (HR 2.12, 95% CI 1.12-4.03), particularly VaD, and all-cause mortality (HR 1.39, 95% CI 1.03-2.00). Vascular risk factors and depressive symptoms did not have any effect modifier on the relationship between reversible cognitive frailty and incident dementia and all-cause mortality.CONCLUSIONS: A model of reversible cognitive frailty was a short- and long-term predictor of all-cause mortality and overall dementia, particularly VaD. The absence of vascular risk factors and depressive symptoms did not modify the predictive role of reversible cognitive frailty on these outcomes.

AB - OBJECTIVES: Cognitive frailty, a condition describing the simultaneous presence of physical frailty and mild cognitive impairment, has been recently defined by an international consensus group. We estimated the predictive role of a "reversible" cognitive frailty model on incident dementia, its subtypes, and all-cause mortality in nondemented older individuals. We verified if vascular risk factors or depressive symptoms could modify this predictive role.DESIGN: Longitudinal population-based study with 3.5- and 7-year of median follow-up.SETTING: Eight Italian municipalities included in the Italian Longitudinal Study on Aging.PARTICIPANTS: In 2150 older individuals from the Italian Longitudinal Study on Aging, we operationalized reversible cognitive frailty with the presence of physical frailty and pre-mild cognitive impairment subjective cognitive decline, diagnosed with a self-report measure based on item 14 of the Geriatric Depression Scale.MEASUREMENTS: Incidence of dementia, its subtypes, and all-cause mortality.RESULTS: Over a 3.5-year follow-up, participants with reversible cognitive frailty showed an increased risk of overall dementia [hazard ratio (HR) 2.30, 95% confidence interval (CI) 1.02-5.18], particularly vascular dementia (VaD), and all-cause mortality (HR 1.74, 95% CI 1.07-2.83). Over a 7-year follow-up, participants with reversible cognitive frailty showed an increased risk of overall dementia (HR 2.12, 95% CI 1.12-4.03), particularly VaD, and all-cause mortality (HR 1.39, 95% CI 1.03-2.00). Vascular risk factors and depressive symptoms did not have any effect modifier on the relationship between reversible cognitive frailty and incident dementia and all-cause mortality.CONCLUSIONS: A model of reversible cognitive frailty was a short- and long-term predictor of all-cause mortality and overall dementia, particularly VaD. The absence of vascular risk factors and depressive symptoms did not modify the predictive role of reversible cognitive frailty on these outcomes.

KW - Journal Article

U2 - 10.1016/j.jamda.2016.10.012

DO - 10.1016/j.jamda.2016.10.012

M3 - Article

C2 - 28012505

VL - 18

SP - 89.e1-89.e8

JO - Journal of the American Medical Directors Association

JF - Journal of the American Medical Directors Association

SN - 1525-8610

IS - 1

ER -