Reversible heart failure in a non-Hodgkin lymphoma patient being treated with alpha-interferon

G. De Simone, V. R. Iaffaioli, G. La Mura, M. D'Avino, G. Costantino, G. Frasci, A. R. Bianco

Research output: Contribution to journalArticlepeer-review

Abstract

We present the case of a 73-year-old patient who developed remarkable contractile failure, simulating dilatative cadiomyopathy, during alpha-interferon (INF) therapy. INF may impair systolic function by a negative metabolic effect on cardiac fiber function. This negative effect may be related to intracellular variation in cyclic adenosine monophosphate levels or to a direct inhibition of contractile protein biosynthesis. The possibility of INF's determining heart failure in our patient was confirmed by the echocardiographic assessment of cardiac mechanics during maximum systolic function impairment, which appeared to be due to contractile failure not counterbalanced by compensatory left ventricular hypertrophy. The rapid enhancement of systolic function after INF withdrawal and digoxin plus diuretic administration also suggested iatrogenic damage.

Original languageEnglish
Pages (from-to)78-85
Number of pages8
JournalCurrent Therapeutic Research
Volume44
Issue number1
Publication statusPublished - 1988

ASJC Scopus subject areas

  • Medicine(all)

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