Reversible self-assembly: A key feature for a new class of autodelivering therapeutic peptides

Thelma A. Pertinhez; Stefania Conti; Elena Ferrari; Walter Magliani; Alberto Spisni; Luciano Polonelli

doi:10.1021/mp900024z

Reversible self-assembly: A key feature for a new class of autodelivering therapeutic peptides

Thelma A. Pertinhez, Stefania Conti, Elena Ferrari, Walter Magliani, Alberto Spisni, Luciano Polonelli

Arcispedale Santa Maria Nuova

Research output: Contribution to journal › Article › peer-review

Abstract

Effective delivery is a critical issue in the use of conventional free drugs. Studies on the structure-function relationship of a therapeutic antibody-derived candidacidal decapeptide (killer peptide, KP) revealed its ability to spontaneously and reversibly self-assemble in an organized network of fibril-like structures. This process is catalyzed by 1,3-β-glucans. While the self-assembled state may provide protection against proteases and the slow kinetic of dissociation assures a release of the active dimeric form over time, the β-glucan affinity is responsible for targeted delivery. Thus, KP represents a novel paradigm of targeted autodelivering drugs.

Original language	English
Pages (from-to)	1036-1039
Number of pages	4
Journal	Molecular Pharmaceutics
Volume	6
Issue number	3
DOIs	https://doi.org/10.1021/mp900024z
Publication status	Published - Jun 1 2009

Keywords

Drug delivery
Killer peptide
Laminarin
Peptide self-assembly

ASJC Scopus subject areas

Pharmaceutical Science
Molecular Medicine
Drug Discovery

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10.1021/mp900024z

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AU - Spisni, Alberto

AU - Polonelli, Luciano

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