Reversible self-assembly: A key feature for a new class of autodelivering therapeutic peptides

Thelma A. Pertinhez, Stefania Conti, Elena Ferrari, Walter Magliani, Alberto Spisni, Luciano Polonelli

Research output: Contribution to journalArticlepeer-review

Abstract

Effective delivery is a critical issue in the use of conventional free drugs. Studies on the structure-function relationship of a therapeutic antibody-derived candidacidal decapeptide (killer peptide, KP) revealed its ability to spontaneously and reversibly self-assemble in an organized network of fibril-like structures. This process is catalyzed by 1,3-β-glucans. While the self-assembled state may provide protection against proteases and the slow kinetic of dissociation assures a release of the active dimeric form over time, the β-glucan affinity is responsible for targeted delivery. Thus, KP represents a novel paradigm of targeted autodelivering drugs.

Original languageEnglish
Pages (from-to)1036-1039
Number of pages4
JournalMolecular Pharmaceutics
Volume6
Issue number3
DOIs
Publication statusPublished - Jun 1 2009

Keywords

  • Drug delivery
  • Killer peptide
  • Laminarin
  • Peptide self-assembly

ASJC Scopus subject areas

  • Pharmaceutical Science
  • Molecular Medicine
  • Drug Discovery

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