Abstract
Effective delivery is a critical issue in the use of conventional free drugs. Studies on the structure-function relationship of a therapeutic antibody-derived candidacidal decapeptide (killer peptide, KP) revealed its ability to spontaneously and reversibly self-assemble in an organized network of fibril-like structures. This process is catalyzed by 1,3-β-glucans. While the self-assembled state may provide protection against proteases and the slow kinetic of dissociation assures a release of the active dimeric form over time, the β-glucan affinity is responsible for targeted delivery. Thus, KP represents a novel paradigm of targeted autodelivering drugs.
Original language | English |
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Pages (from-to) | 1036-1039 |
Number of pages | 4 |
Journal | Molecular Pharmaceutics |
Volume | 6 |
Issue number | 3 |
DOIs | |
Publication status | Published - Jun 1 2009 |
Keywords
- Drug delivery
- Killer peptide
- Laminarin
- Peptide self-assembly
ASJC Scopus subject areas
- Pharmaceutical Science
- Molecular Medicine
- Drug Discovery