Reversible self-assembly: A key feature for a new class of autodelivering therapeutic peptides

Thelma A. Pertinhez, Stefania Conti, Elena Ferrari, Walter Magliani, Alberto Spisni, Luciano Polonelli

Research output: Contribution to journalArticle

Abstract

Effective delivery is a critical issue in the use of conventional free drugs. Studies on the structure-function relationship of a therapeutic antibody-derived candidacidal decapeptide (killer peptide, KP) revealed its ability to spontaneously and reversibly self-assemble in an organized network of fibril-like structures. This process is catalyzed by 1,3-β-glucans. While the self-assembled state may provide protection against proteases and the slow kinetic of dissociation assures a release of the active dimeric form over time, the β-glucan affinity is responsible for targeted delivery. Thus, KP represents a novel paradigm of targeted autodelivering drugs.

Original languageEnglish
Pages (from-to)1036-1039
Number of pages4
JournalMolecular Pharmaceutics
Volume6
Issue number3
DOIs
Publication statusPublished - Jun 1 2009

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Glucans
Peptides
Pharmaceutical Preparations
Peptide Hydrolases
Antibodies
Therapeutics

Keywords

  • Drug delivery
  • Killer peptide
  • Laminarin
  • Peptide self-assembly

ASJC Scopus subject areas

  • Pharmaceutical Science
  • Molecular Medicine
  • Drug Discovery

Cite this

Pertinhez, T. A., Conti, S., Ferrari, E., Magliani, W., Spisni, A., & Polonelli, L. (2009). Reversible self-assembly: A key feature for a new class of autodelivering therapeutic peptides. Molecular Pharmaceutics, 6(3), 1036-1039. https://doi.org/10.1021/mp900024z

Reversible self-assembly : A key feature for a new class of autodelivering therapeutic peptides. / Pertinhez, Thelma A.; Conti, Stefania; Ferrari, Elena; Magliani, Walter; Spisni, Alberto; Polonelli, Luciano.

In: Molecular Pharmaceutics, Vol. 6, No. 3, 01.06.2009, p. 1036-1039.

Research output: Contribution to journalArticle

Pertinhez, TA, Conti, S, Ferrari, E, Magliani, W, Spisni, A & Polonelli, L 2009, 'Reversible self-assembly: A key feature for a new class of autodelivering therapeutic peptides', Molecular Pharmaceutics, vol. 6, no. 3, pp. 1036-1039. https://doi.org/10.1021/mp900024z
Pertinhez TA, Conti S, Ferrari E, Magliani W, Spisni A, Polonelli L. Reversible self-assembly: A key feature for a new class of autodelivering therapeutic peptides. Molecular Pharmaceutics. 2009 Jun 1;6(3):1036-1039. https://doi.org/10.1021/mp900024z
Pertinhez, Thelma A. ; Conti, Stefania ; Ferrari, Elena ; Magliani, Walter ; Spisni, Alberto ; Polonelli, Luciano. / Reversible self-assembly : A key feature for a new class of autodelivering therapeutic peptides. In: Molecular Pharmaceutics. 2009 ; Vol. 6, No. 3. pp. 1036-1039.
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