Abstract
Effective delivery is a critical issue in the use of conventional free drugs. Studies on the structure-function relationship of a therapeutic antibody-derived candidacidal decapeptide (killer peptide, KP) revealed its ability to spontaneously and reversibly self-assemble in an organized network of fibril-like structures. This process is catalyzed by 1,3-β-glucans. While the self-assembled state may provide protection against proteases and the slow kinetic of dissociation assures a release of the active dimeric form over time, the β-glucan affinity is responsible for targeted delivery. Thus, KP represents a novel paradigm of targeted autodelivering drugs.
| Original language | English |
|---|---|
| Pages (from-to) | 1036-1039 |
| Number of pages | 4 |
| Journal | Molecular Pharmaceutics |
| Volume | 6 |
| Issue number | 3 |
| DOIs | |
| Publication status | Published - Jun 1 2009 |
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Keywords
- Drug delivery
- Killer peptide
- Laminarin
- Peptide self-assembly
ASJC Scopus subject areas
- Pharmaceutical Science
- Molecular Medicine
- Drug Discovery
Cite this
Reversible self-assembly : A key feature for a new class of autodelivering therapeutic peptides. / Pertinhez, Thelma A.; Conti, Stefania; Ferrari, Elena; Magliani, Walter; Spisni, Alberto; Polonelli, Luciano.
In: Molecular Pharmaceutics, Vol. 6, No. 3, 01.06.2009, p. 1036-1039.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Reversible self-assembly
T2 - A key feature for a new class of autodelivering therapeutic peptides
AU - Pertinhez, Thelma A.
AU - Conti, Stefania
AU - Ferrari, Elena
AU - Magliani, Walter
AU - Spisni, Alberto
AU - Polonelli, Luciano
PY - 2009/6/1
Y1 - 2009/6/1
N2 - Effective delivery is a critical issue in the use of conventional free drugs. Studies on the structure-function relationship of a therapeutic antibody-derived candidacidal decapeptide (killer peptide, KP) revealed its ability to spontaneously and reversibly self-assemble in an organized network of fibril-like structures. This process is catalyzed by 1,3-β-glucans. While the self-assembled state may provide protection against proteases and the slow kinetic of dissociation assures a release of the active dimeric form over time, the β-glucan affinity is responsible for targeted delivery. Thus, KP represents a novel paradigm of targeted autodelivering drugs.
AB - Effective delivery is a critical issue in the use of conventional free drugs. Studies on the structure-function relationship of a therapeutic antibody-derived candidacidal decapeptide (killer peptide, KP) revealed its ability to spontaneously and reversibly self-assemble in an organized network of fibril-like structures. This process is catalyzed by 1,3-β-glucans. While the self-assembled state may provide protection against proteases and the slow kinetic of dissociation assures a release of the active dimeric form over time, the β-glucan affinity is responsible for targeted delivery. Thus, KP represents a novel paradigm of targeted autodelivering drugs.
KW - Drug delivery
KW - Killer peptide
KW - Laminarin
KW - Peptide self-assembly
UR - http://www.scopus.com/inward/record.url?scp=67249127511&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=67249127511&partnerID=8YFLogxK
U2 - 10.1021/mp900024z
DO - 10.1021/mp900024z
M3 - Article
C2 - 19366260
AN - SCOPUS:67249127511
VL - 6
SP - 1036
EP - 1039
JO - Molecular Pharmaceutics
JF - Molecular Pharmaceutics
SN - 1543-8384
IS - 3
ER -