Reversible tubular proteinuria precedes microalbuminuria and correlates with the metabolic status in diabetic children

Fabrizio Ginevri, Emanuela Piccotti, Rossella Alinovi, Teresa DeToni, Claudia Biagini, Gian Marco Chiggeri, Rosanna Gusmano

Research output: Contribution to journalArticle

Abstract

Early tubular alterations were studied in 53 children with insulin-dependent diabetes mellitus (IDDM), 32 of whom were followed at regular 6-monthly intervals for 3 years. The urinary levels of retinol-binding protein (RBP), β2-microglobulin and brush border antigens and brush border antigens (BBA) (determined by monoclonal enzyme immunoassay) were taken as indices of functional and cellular tubular alterations; urinary albumin was considered an early marker of glomerular alterations. All indices of tubular alterations were higher in IDDM children than in 368 normal children, while albuminuria was unchanged. Urinary levels of BBA, however, varied widely during follow-up, with 25 of the 32 IDDM patients who were followed at regular intervals having pathological values for BBA on at least one occasion, folowed by normalization. Metabolic alteration was found to be the main cause of this variability, since a high statistical correlation was found between urinary BBA and fructosamine (P

Original languageEnglish
Pages (from-to)23-26
Number of pages4
JournalPediatric Nephrology
Volume7
Issue number1
DOIs
Publication statusPublished - Feb 1993

Keywords

  • Albuminuria
  • Brush border antigens
  • Diabetes mellitus
  • Metabolic control
  • Tubular changes

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Nephrology

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