Reversible tubular proteinuria precedes microalbuminuria and correlates with the metabolic status in diabetic children

Fabrizio Ginevri; Emanuela Piccotti; Rossella Alinovi; Teresa DeToni; Claudia Biagini; Gian Marco Chiggeri; Rosanna Gusmano

doi:10.1007/BF00861555

Reversible tubular proteinuria precedes microalbuminuria and correlates with the metabolic status in diabetic children

Fabrizio Ginevri, Emanuela Piccotti, Rossella Alinovi, Teresa DeToni, Claudia Biagini, Gian Marco Chiggeri, Rosanna Gusmano

Istituto "Giannina Gaslini"

Research output: Contribution to journal › Article

Abstract

Early tubular alterations were studied in 53 children with insulin-dependent diabetes mellitus (IDDM), 32 of whom were followed at regular 6-monthly intervals for 3 years. The urinary levels of retinol-binding protein (RBP), β₂-microglobulin and brush border antigens and brush border antigens (BBA) (determined by monoclonal enzyme immunoassay) were taken as indices of functional and cellular tubular alterations; urinary albumin was considered an early marker of glomerular alterations. All indices of tubular alterations were higher in IDDM children than in 368 normal children, while albuminuria was unchanged. Urinary levels of BBA, however, varied widely during follow-up, with 25 of the 32 IDDM patients who were followed at regular intervals having pathological values for BBA on at least one occasion, folowed by normalization. Metabolic alteration was found to be the main cause of this variability, since a high statistical correlation was found between urinary BBA and fructosamine (P

Original language	English
Pages (from-to)	23-26
Number of pages	4
Journal	Pediatric Nephrology
Volume	7
Issue number	1
DOIs	https://doi.org/10.1007/BF00861555
Publication status	Published - Feb 1993

Keywords

Albuminuria
Brush border antigens
Diabetes mellitus
Metabolic control
Tubular changes

ASJC Scopus subject areas

Pediatrics, Perinatology, and Child Health
Nephrology

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10.1007/BF00861555

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Ginevri, F., Piccotti, E., Alinovi, R., DeToni, T., Biagini, C., Chiggeri, G. M., & Gusmano, R. (1993). Reversible tubular proteinuria precedes microalbuminuria and correlates with the metabolic status in diabetic children. Pediatric Nephrology, 7(1), 23-26. https://doi.org/10.1007/BF00861555

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abstract = "Early tubular alterations were studied in 53 children with insulin-dependent diabetes mellitus (IDDM), 32 of whom were followed at regular 6-monthly intervals for 3 years. The urinary levels of retinol-binding protein (RBP), β2-microglobulin and brush border antigens and brush border antigens (BBA) (determined by monoclonal enzyme immunoassay) were taken as indices of functional and cellular tubular alterations; urinary albumin was considered an early marker of glomerular alterations. All indices of tubular alterations were higher in IDDM children than in 368 normal children, while albuminuria was unchanged. Urinary levels of BBA, however, varied widely during follow-up, with 25 of the 32 IDDM patients who were followed at regular intervals having pathological values for BBA on at least one occasion, folowed by normalization. Metabolic alteration was found to be the main cause of this variability, since a high statistical correlation was found between urinary BBA and fructosamine (P",

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AU - Alinovi, Rossella

AU - DeToni, Teresa

AU - Biagini, Claudia

AU - Chiggeri, Gian Marco

AU - Gusmano, Rosanna

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N2 - Early tubular alterations were studied in 53 children with insulin-dependent diabetes mellitus (IDDM), 32 of whom were followed at regular 6-monthly intervals for 3 years. The urinary levels of retinol-binding protein (RBP), β2-microglobulin and brush border antigens and brush border antigens (BBA) (determined by monoclonal enzyme immunoassay) were taken as indices of functional and cellular tubular alterations; urinary albumin was considered an early marker of glomerular alterations. All indices of tubular alterations were higher in IDDM children than in 368 normal children, while albuminuria was unchanged. Urinary levels of BBA, however, varied widely during follow-up, with 25 of the 32 IDDM patients who were followed at regular intervals having pathological values for BBA on at least one occasion, folowed by normalization. Metabolic alteration was found to be the main cause of this variability, since a high statistical correlation was found between urinary BBA and fructosamine (P

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