Review article: Endoscopic antireflux procedures - An unfulfilled promise?

F. Pace, G. Costamagna, R. Penagini, A. Repici, V. Annese

Research output: Contribution to journalArticlepeer-review


Background: Most published reviews concerning the endoscopic treatment of gastro-oesophageal reflux disease date back to 2005. Aim: To provide an updated review that includes all papers published up to 2007. Methods: A Medline search from January 2005 to June 2007 was performed regarding endoscopic procedures aiming at treating gastro-oesophageal reflux disease. In addition, we retrieved the abstracts presented at Digestive Disease Week during the last 3 years. We included in the review both 'mechanistic' studies - that is, papers exploring the potential mechanism of action of the procedure/device - and studies trying to assess its clinical efficacy. Results: During the last 3 years, the number of published papers has declined, and some devices are not available any more. The alleged mechanism(s) of action of the various devices or procedures is (are) still not completely elucidated; however, some concerns have arisen as far as durability and potential detrimental effects. Moreover, all the aspects of endoscopic therapy, except for its safety, are either insufficiently explored or not investigated at all, or assessed only in particularly selected patient subgroups. Conclusions: None of the proposed antireflux therapies has fulfilled the criteria of efficacy, safety, cost, durability and, possibly, of reversibility. There is at present no definite indication for endoscopic therapy of gastro-oesophageal reflux disease. We suggest a list of recommendations to be followed when a new endoscopic therapeutic procedure is to be assessed for use in clinical practice.

Original languageEnglish
Pages (from-to)375-384
Number of pages10
JournalAlimentary Pharmacology and Therapeutics
Issue number5
Publication statusPublished - Mar 2008

ASJC Scopus subject areas

  • Pharmacology (medical)
  • Pharmacology, Toxicology and Pharmaceutics(all)


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