Review article: Plasticity of spinal centers in spinal cord injury patients: New concepts for gait evaluation and training

Giorgio Scivoletto, Yuri Ivanenko, Barbara Morganti, Renato Grasso, Mirka Zago, Francesco Lacquaniti, John Ditunno, Marco Molinari

Research output: Contribution to journalArticlepeer-review

Abstract

Recent data on spinal cord plasticity after spinal cord injury (SCI) were reviewed to analyze the influence of training on the neurophysiological organization of locomotor spinal circuits in SCI patients. In particular, the authors studied the relationship between central pattern generators (CPGs) and motor neuron pool activation during gait. An analysis of the relations between locomotor recovery and compensatory mechanisms focuses on the hierarchical organization of gait parameters and allows characterizing kinematic parameters that are highly stable during different gait conditions and in recovered gait after SCI. The importance of training characteristics and the use of robotic/automated devices in gait recovery is analyzed and discussed. The role of CPG in defining kinematic gait parameters is summarized, and spatio-temporal maps of EMG activity during gait are used to clarify the role of CPG plasticity in sustaining gait recovery.

Original languageEnglish
Pages (from-to)358-365
Number of pages8
JournalNeurorehabilitation and Neural Repair
Volume21
Issue number4
DOIs
Publication statusPublished - Jan 2007

Keywords

  • Central pattern generator
  • Neuronal plasticity
  • Spinal cord injury
  • Walking rehabilitation

ASJC Scopus subject areas

  • Rehabilitation
  • Clinical Neurology
  • Neuroscience(all)
  • Health Professions(all)

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