Review of the implications of dietary tryptophan intake in patients with irritable bowel syndrome and psychiatric disorders

A. Agazzi, F. De Ponti, R. De Giorgio, S. M. Candura, L. Anselmi, E. Cervio, A. Di Nucci, Marcello Tonini

Research output: Contribution to journalArticle

Abstract

In this review, we address the possible role of the essential amino acid L-tryptophan or its metabolic derivative 5-hydroxytryptophan in the modulation of serotonin (5-hydroxytryptamine) synthesis and thereby in affecting the pathophysiology of central and peripheral nervous system disorders, including depression and irritable bowel syndrome. L-Tryptophan may represent a link between apparently disparate functional disorders and is of interest for general gastroenterologists, neurogastroenterologists, and neurologists. On the basis of estimates showing that approximately 20% of patients with functional bowel disorders seeking care in referral centres have psychiatric comorbidity, we attempt to provide a conceptual framework for defining the possible role of L-tryptophan in this population.

Original languageEnglish
Pages (from-to)590-595
Number of pages6
JournalDigestive and Liver Disease
Volume35
Issue number8
DOIs
Publication statusPublished - Aug 2003

Keywords

  • Irritable bowel syndrome
  • Psychiatric disorders
  • Tryptophan

ASJC Scopus subject areas

  • Gastroenterology

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